Sarinex D

• Allergic rhinitis
• Common cold and nasal congestion
• Sneezing, itching, watery eyes
• Hives, skin rash

Desloratadine is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils. Pseudoephedrine is both an α- and β-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of α-adrenergic receptors of the respiratory mucosa and also directly stimulates β-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

Adults: 1 tablet (2.5 mg desloratadine/120 mg pseudoephedrine) every 12 hours; OR 1 tablet (5 mg/240 mg) every 24 hours.
Children (≥12 years): Same as adult dosing.
Hepatic/renal impairment: Not recommended.

Desloratadine (>10%): Fever (12%), Irritability (12%), Headache (12%), Diarrhea (15-21%), Cough (11%), Upper respiratory tract infection (11-21%).
Desloratadine (1-10%): Pharyngitis (4.1%), Dry mouth (3%), Myalgia (2.1%), Emotional lability (3%), Erythema (3%), Macopapular rash (3%), Dizziness (4%), Fatigue (2.1%), Somnolence (2.1%), UTI (4%), Dyspepsia (3%), Insomnia (5%), Dysmenorrhea (2.1%).
Pseudoephedrine: CNS (tremor, restlessness), Insomnia, Arrhythmia, Hypotension, Tachycardia, Fatigue, Rash, Urticaria, Anorexia, Xerostomia, Dysuria, Polyuria, Nausea, Vomiting, Ischemic colitis.

Limited data in pregnant women; not sufficient to inform drug-associated risk for major birth defects and miscarriage. Most studies did not find association with increased risk of congenital anomalies with pseudoephedrine.

Severe renal or hepatic failure; children <6 months; elderly; epilepsy; pregnancy and lactation. Both drugs pass into breast milk; pseudoephedrine is concentrated in breast milk.

No adequate information on overdose is available.

Store in a cool and dry place, protected from light.