৳ 130.39/unit
Pack: ৳ 130.39
৳ 130.39/unit
Pack: ৳ 130.39
At a glance
Ethosuximide is an anticonvulsant medication used for the control of absence (petit mal) seizures.
Indications
- Absence Seizures: Indicated for the control of absence (petit mal) seizures.
Pharmacology
Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli.
Dosage
Adult Dose (Oral):
- Initial: 500 mg daily (single or divided doses)
- Increase: 250 mg every 4-7 days
- Usual dose: 1-1.5 g daily
- Max: Up to 2 g in some patients
- Optimum plasma concentration: 40-100 mg/L
Child Dose (3-6 years): Initial: 5 mL (250 mg)/day; increase by 5 mL (250 mg) every 4-7 days; usual maintenance: 20 mg/kg or 1.2 g/m²/day.
Child Dose (>=6 years): Initial: 10 mL (500 mg)/day; increase by 5 mL (250 mg) every 4-7 days.
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Fatigue
- Indigestion
- Stomach pain
- Dizziness
- Lightheadedness
- Diarrhea
- Weight loss
- Headache
- Loss of appetite
- Hiccup
- Ataxia
- Irritability, aggression
Rare Side Effects: Tongue swelling, sleep disturbances, depression, psychosis, photophobia, dyskinesia, vaginal bleeding, myopia, gingival hypertrophy, rash, blood disorders (leucopenia, agranulocytosis, pancytopenia, aplastic anaemia), SLE, Stevens-Johnson syndrome.
Use in pregnancy
Use in Pregnancy: Ethosuximide may be unsafe; animal studies have shown harmful effects on the developing baby.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Ethosuximide may affect your ability to drive; do not drive until you know how it affects you.
- Take it only as per dose and duration prescribed by your doctor.
- It may cause dizziness; do not do anything that requires mental focus.
- Your doctor may get regular tests done to monitor kidney function, liver function, and blood cell levels.
- Inform your doctor if you notice changes in mood, behavior or if you have suicidal thoughts.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
- Do not stop taking medication suddenly without talking to your doctor (can worsen seizures).
Overdose effects
Overdose: Acute overdoses may produce nausea, vomiting and CNS depression including coma.
Storage conditions
Storage: Store in a cool and dry place protected from light. Keep out of reach of children.