oshudhkosh

Servizid300mg

Rx
Generic:
Isoniazid
Dosage form:
Tablet
Pack size:
Tablet

৳ 0.61/unit

Pack: ৳ 0.61

At a glance

Isoniazid — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Isoniazid is an antibiotic used for the treatment and prevention of tuberculosis (TB) and inactive (latent) TB (a serious infection caused by bacteria that affects the lungs and in certain cases other parts of the body). It works by killing the bacteria that cause tuberculosis. Isoniazid should be used in the dose and duration as advised by your doctor. It is to be taken on an empty stomach. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early can result in treatment failure and increase the side effects too. Do not take a double dose to make up for a missed dose. Simply take the next dose as planned. It may cause tingling and numbness of feet and hand (peripheral neuropathy) as a side effect of this medicine. Inform your doctor if you notice signs of jaundice i.e. yellowing of eyes or skin, dark urine, stomach pain or joint pain. You may also develop hepatitis (viral infection of the liver) or increased liver enzymes as side effects of this medicine. Please consult your doctor, as these side effects require medical attention and need dose modification. Your doctor may monitor your liver function while on treatment with this medicine. Avoid drinking alcohol as this may have additional adverse effects on the liver. Pregnant or breastfeeding women should consult their doctor before using this medicine. Isoniazid is an antibiotic. It works by killing the bacteria that causes tuberculosis.

Indications

• Tuberculosis (TB)

Mechanism of action

Isoniazid inhibits the synthesis of mycoloic acids in susceptible bacteria which results in loss of acid-fastness and disruption of bacterial cell wall. At therapeutic levels, it is bacteriocidal against actively growing intracellular and extracellular Mycobacterium tuberculosis organisms.

Dosage

Adult Dose: Oral Active Tuberculosis Disease 5 mg/kg PO qDay, not to exceed 300 mg qDay 15 mg/kg PO up; not to exceed 900 mg 1-3 times/week Used in multi-drug regimen containing rifampin (or ribabutin or rifapentin), pyrazinamide, and ethambutol Latent Tuberculosis Infection Treatment of latent TB infection greatly reduces the risk that TB infection will progress to acitve disease >30 kg: 300 mg PO qDay x9 months Child Dose: Active Tuberculosis Disease 10-15 mg/kg PO qDay; not to exceed 300 mg/day OR 20-30 mg/kg (up to 900 mg) 2 times/week Used in multi-drug regimen Latent Tuberculosis Infection Treatment of latent TB infection greatly reduces the risk that TB infection will progress to acitve disease 10-15 mg/kg PO qDay; not to exceed 300 mg/day Renal Dose: Renal impairment: Severe: Dose reduction may be needed.

Administration

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isoniazid is to be taken empty stomach. Avoid Isoniazid with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.

Missed dose

If you miss a dose of Isoniazid, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Side effects

Common: • Peripheral neuropathy (tingling and numbness of feet and hand) • Increased liver enzymes • Hepatitis (viral infection of liver) • Jaundice

Precautions & warnings

[UNSAFE] Isoniazid may cause side effects which could affect your ability to drive. Isoniazid can cause fits, mental health problems and optic neuritis (inflammation of the optic nerve that may cause loss of vision.) This may affect your driving ability. Your doctor has prescribed Isoniazid to cure your infection and improve symptoms. It is best taken on an empty stomach. You must also take a vitamin B6 supplement while on Isoniazid. Tell your doctor immediately if you experience vision changes, loss of appetite, tiredness, stomach pain, nausea or vomiting, yellow skin or eyes or dark-colored urine.

Contraindications

Acute liver disease or history of hepatic damage during INH therapy; hypersensitivity.

Drug interactions

Inhibit the hepatic metabolism of antiepileptics (e.g. carbamazepine, ethosuximide, primidone, phenytoin), benzodiazepines (e.g. diazepam, triazolam), chlorzoxazone, theophylline, disulfiram, sometimes leading to increased toxicity. Increased metabolism of enflurane, resulting in potentially nephrotoxic levels of fluoride. Increased concentrations and enhanced effects or toxicity of clofazimine, cycloserine and warfarin. Reduced absorption w/ Al-containing antacids. Increased risk of peripheral neuropathy w/ zalcitabine and stavudine.

Food interactions

[UNSAFE] Consuming alcohol while taking Isoniazid may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

Use in pregnancy

[CONSULT YOUR DOCTOR] Isoniazid may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

Use in lactation

[SAFE IF PRESCRIBED] Isoniazid is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Renal / hepatic impairment

[SAFE IF PRESCRIBED] Isoniazid is safe to use in patients with kidney disease. No dose adjustment of Isoniazid is recommended. However, talk to your doctor if you have any underlying kidney disease. [CAUTION] Isoniazid should be used with caution in patients with liver disease. Dose adjustment of Isoniazid may be needed. Please consult your doctor. Use of Isoniazid is not recommended in patients with severe liver disease.

Common questions

I had ectopic pregnancy as advice by dr.I had gone for laparoscopy for my other tube and after dat she gave me this medication ISONIAZID, PYRAZINAMIDE 750mg,PYRICO TIN, COMBUTOL600 which I had checked online dis all tablets r for TB so should I continue or stop If u have been diagnosed with tuberculosis then start otherwise not My daughter is given tb medicine even though she is not infected taking these medicine will cause tb??? Hello, TB medicines are given only when there is indication of tuberculosis. They are for treating tuberculosis. Though took vaccines in childhood, the test for TB came positive. Was advised to undergo treatment.physically absolute fit and healthy, is it advisable to take treatment? If sputum is positive for Tb , treatment is absolutely essential. Read more at www.arohealth.com/tuberculosis Extra pulmonary tuberculosis mdr tb for spinal card treatment This needs to be examined and treated in the clinic Whats r Various pathological test for me tuberculosis???? Dear PATIENT various tests which you use for MDR Tuberculosis are: Genexpert test which basically detects the DNA of TB bacteria, microarrays, Phage assyas etc. Sir my aunt has lymph node tuberculosis she had all the TB medicine course completely but no cure plzz prescribe her effective ayurvadic medice of lymph node tuberculosis Kindly send your reports on E-mail at : Fluid in lungs, in fluid sample tuberculosis positive any solution? Sir if TB is positive the best treatment is to take Anti Tuberculosis Treatment (ATT) from GOVT authorised ATT centres. But you can also add homeopathy for improvement in general health. I have cough problem from 25 days. I used penther syrup, tuspel cough syrup and tuff DMR , DMR 20 tablet, Roxud 150 mg but no much recovery so prescribe me for that. refer to chest specialist and do test for tuberculosis

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.