৳ 4,000/unit
Pack: ৳ 4,000
৳ 4,000/unit
Pack: ৳ 4,000
At a glance
Levosimendan is indicated for the short-term treatment of acute heart failure (AHF) in situations where conventional therapy is not sufficient and inotropic support is considered appropriate.
Indications
- Acute heart failure (AHF) - when conventional therapy is not sufficient and inotropic support is appropriate
Pharmacology
Levosimendan binds to troponin C to increase calcium sensitivity of myofibrils (inotropic effect) and opens ATP-sensitive potassium channels in vascular smooth muscle to cause vasodilation.
Dosage
Adult Dose (IV Infusion):
- Loading dose: 6-12 mcg/kg IV over 10 minutes
- Followed by continuous infusion: 0.1 mcg/kg/min
- With concomitant vasodilators/inotropes: 6 mcg/kg loading dose
- Adjust 0.05-0.2 mcg/kg/min based on response
- Recommended infusion duration: 24 hours
Side effects
Common Side Effects:
- Ventricular tachycardia
- Hypotension
- Headache
- Atrial fibrillation
- Ventricular extrasystoles
- Tachycardia
Use in pregnancy
Use in Pregnancy: No experience in pregnant women; animal studies have shown reproductive toxicity. Use only if benefits for the mother outweigh risks to the fetus.
Precautions & warnings
- Reduce or stop infusion if hypotension or tachycardia occurs after loading dose
- Correct severe hypovolaemia before infusion
- Monitor and correct serum potassium
- Caution in ischemic heart disease, anemia, arrhythmias
- Caution with QTc-prolonging drugs
Overdose effects
Overdose may cause hypotension and tachycardia; treat with vasopressors (dopamine, adrenaline).
Storage conditions
Store in a refrigerator (2-8°C); do not freeze.