৳ 22/unit
Pack: ৳ 440
৳ 22/unit
Pack: ৳ 440
At a glance
Metformin Hydrochloride + Sitagliptin is a combination medicine that controls high blood sugar levels in type 2 diabetes mellitus. Metformin reduces glucose production and absorption, and Sitagliptin is a DPP-4 inhibitor that increases incretin hormone activity.
Indications
- Type 2 diabetes mellitus - as an adjunct to diet and exercise to improve glycemic control
Pharmacology
Metformin reduces glucose production and absorption; Sitagliptin inhibits DPP-4 to increase incretin hormone levels, which stimulates glucose-dependent insulin release and reduces glucagon secretion.
Dosage
Immediate Release (Adult):
- Not on metformin: 50/500 mg twice daily
- On metformin: Sitagliptin 50 mg twice daily + current metformin dose
- Maximum: Sitagliptin 100 mg + Metformin 2000 mg/day
Extended Release (Adult):
- Initial: Sitagliptin 50/100 mg + Metformin ER 500/1000 mg once daily (evening)
- Maximum: Sitagliptin 100 mg + Metformin ER 2000 mg/day
Side effects
Common Side Effects (≥5%):
- Diarrhea
- Upper respiratory tract infection
- Headache
- Hypoglycemia (with sulfonylurea or insulin)
- Nausea, vomiting, upset stomach
Use in pregnancy
Use in Pregnancy: Metformin + Sitagliptin is generally considered safe during pregnancy (Category B); animal studies have shown low or no adverse effects.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Inform doctor if symptoms of lactic acidosis occur (deep/rapid breathing, persistent nausea, vomiting, abdominal pain)
- Monitor blood sugar regularly to avoid hypoglycemia
- Avoid alcohol (risk of lactic acidosis)
- Temporarily stop before major surgery or contrast dye procedures
- Caution in history of pancreatitis
Overdose effects
Overdose may cause lactic acidosis; sitagliptin is modestly dialyzable; metformin is dialyzable.
Storage conditions
Store below 25°C in a dry place, away from light; keep out of reach of children.