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Company•Renata Limited

Sofenib 200

Rx
Generic: Sorafenib

৳ 300/unit

Pack: ৳ 1,200

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At a glance

Sorafenib is a tyrosine kinase inhibitor used for the treatment of unresectable hepatocellular carcinoma, advanced renal cell carcinoma, and thyroid cancer. It inhibits tumor cell proliferation and angiogenesis.

Indications
  • Unresectable hepatocellular carcinoma (HCC)
  • Advanced renal cell carcinoma (RCC)
  • Thyroid cancer
Pharmacology

Sorafenib inhibits multiple intracellular kinases (CRAF, BRAF, mutant BRAF) and cell surface kinases (VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-β, KIT, FLT-3, RET). It blocks RAF/MEK/ERK signaling and VEGF-mediated angiogenesis, reducing tumor cell proliferation and tumor angiogenesis.

Dosage

Adult Dose (Oral):

  • Recommended: 400 mg twice daily (without food, 1 hour before or 2 hours after a meal)
  • Continue until clinical benefit or unacceptable toxicity
  • Dose reduction: 400 mg once daily; if needed, 400 mg every other day
Side effects

Common Side Effects:

  • Fatigue
  • Nausea, loss of appetite
  • Diarrhea, abdominal pain
  • Hair loss, weight loss
  • Rash, painful blisters on hands and feet (hand-foot skin reaction)

Serious:

  • Cardiac ischemia/infarction
  • Hemorrhage, hypertension
  • Gastrointestinal perforation
Use in pregnancy

Use in Pregnancy: Unsafe (Category D); evidence of fetal risk; use only in life-threatening situations; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Cardiac ischemia/infarction: Consider temporary or permanent discontinuation
  • Hemorrhage: Consider permanent discontinuation if medical intervention needed
  • Hypertension: Regular monitoring; temporary/permanent discontinuation for severe or persistent
  • GI perforation: Discontinue
  • With warfarin: Monitor INR/prothrombin time
Overdose effects

No specific antidote; highest clinical dose 800 mg twice daily; diarrhea and dermatologic reactions are primary; provide symptomatic treatment.

Storage conditions

Store at room temperature below 30°C; do not remove desiccant; dispense in original bottle.

Sorafenib — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.