Steclo NN

• Psoriasis (excluding widespread plaque psoriasis, where secondary bacterial or fungal infection is present, suspected or likely to occur)
• Eczema (short courses treatment of recalcitrant eczemas)
• Neurodermatoses
• Other inflammatory conditions which do not respond satisfactorily to less active steroids

Clobetasol Propionate is a highly active corticosteroid with topical anti-inflammatory activity. The major effect of Clobetasol Propionate on skin is a nonspecific anti-inflammatory response, partially due to vasoconstriction and decrease in collagen synthesis. Neomycin binds to the ribosomal 30s and 50s sub-units of susceptible bacteria and inhibits protein synthesis. Nystatin acts by binding to sterols in the cell membrane of the fungus with a resultant change in membrane permeability allowing leakage of intracellular components.

Adult Dose (Topical): Apply a thin layer onto the affected area(s) 1-2 times daily until improvement occurs. Not to be used for >7 days without medical supervision. If a longer course is necessary, treatment should not be continued for more than 4 weeks without the patient's condition being reviewed.

Pediatric Dose (>2 years): Same as adult dose. Not recommended for neonates and infants (younger than 2 years).

Common Side Effects:

• Perioral dermatitis
• Striae (especially in flexures)
• Dermal and epidermal atrophy (especially on the face)
• Steroid purpura
• Pigmentation changes
• Hypertrichosis

Serious Side Effects (long-term/large area use): Hypercortisolism (adrenal suppression), Cushing's syndrome, diabetes, hypertension.

There is little information to demonstrate the possible effect of topically applied Neomycin in pregnancy. Neomycin present in maternal blood can cross the placenta and may give rise to a theoretical risk of fetal toxicity. Use is not recommended during pregnancy and lactation.

• Long-term continuous topical therapy should be avoided where possible, particularly in infants and children (adrenal suppression can occur readily even without occlusion).
• If used in childhood, or on the face, courses should be limited to 5 days and occlusion should not be used.
• If applied to the eyelids, care is needed to ensure that the preparation does not enter the eye (glaucoma might result).
• If used in psoriasis, careful patient supervision is important.
• Flammable; do not use or dry the hair near a fire or flame.
• Not recommended during pregnancy and lactation.

Acute overdosage is very unlikely to occur. In the case of chronic overdosage or misuse, features of hypercortisolism may appear; topical steroids should be discontinued gradually.

Store below 25°C temperature. Do not freeze. Keep out of reach of children.