৳ 4,405/unit
Pack: ৳ 4,405
৳ 4,405/unit
Pack: ৳ 4,405
At a glance
Somatostatin is a polypeptide hormone used for the treatment of acromegaly, carcinoid tumors, and bleeding esophageal varices. It inhibits growth hormone, thyrotrophin, and glucagon secretion and reduces bleeding by constricting blood vessels.
Indications
- Acromegaly
- Carcinoid tumors
- Bleeding esophageal varices
Pharmacology
Somatostatin inhibits the release of growth hormone (GH), thyrotrophin (TSH), and corticotropin (ACTH) from the anterior pituitary. It also inhibits glucagon and insulin secretion from the pancreas and regulates duodenal and gastric secretions. In esophageal varices, it reduces bleeding by constricting blood vessels.
Dosage
Adult Dose (IV):
- GI hemorrhage: Initially 250 mcg bolus injection (over 3-5 min), then continuous infusion of 3.5 mcg/kg/hr until bleeding stops; may continue for 48-72 hours to prevent recurrence
Side effects
Common Side Effects:
- Diarrhea
- Abdominal pain
- Constipation, flatulence
- Headache
- Increased blood glucose levels
- Injection site reaction
- Gallstones (with long-term use)
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Inform doctor if you have liver problems
- Monitor blood glucose regularly
- Long-term use: Monitor thyroid, gallbladder, liver function, and vitamin B12
- Caution in pregnancy and lactation
Overdose effects
No overdose information available; excessive doses may increase side effects; consult your doctor.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.