৳ 8.03/unit
Pack: ৳ 8.03
৳ 8.03/unit
Pack: ৳ 8.03
At a glance
Atomoxetine is a non-stimulant medicine used in the treatment of attention deficit hyperactivity disorder (ADHD) in children, adolescents, and adults. It improves attention span, concentration, and reduces impulsive behavior.
Indications
- Attention-Deficit/Hyperactivity Disorder (ADHD) in pediatric patients (ages 6 and older), adolescents, and adults
Pharmacology
Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI). It inhibits the pre-synaptic norepinephrine transporter, increasing norepinephrine levels in the synaptic cleft. It has weak affinity for the dopamine transporter and no significant affinity for other neurotransmitter receptors or transporters.
Atomoxetine increases norepinephrine activity in cortical and limbic areas in patients with ADHD. It improves the balance of dopamine and norepinephrine in the prefrontal cortex, which enhances attention, memory, and impulse control. Unlike stimulants, it does not directly block the dopamine transporter, resulting in lower addiction potential.
Dosage
Children & Adolescents (6 years+) - ADHD:
- Body weight ≤70 kg: Initial dose 40 mg/day (once daily or divided into 2 doses). May increase to 80 mg/day after at least 7 days. May increase to 100 mg/day after 2-4 weeks if needed.
- Body weight >70 kg: Initial dose 40 mg/day (once daily or divided into 2 doses). May increase to 80 mg/day after at least 7 days. May increase to 100 mg/day after 2-4 weeks if needed.
Adults - ADHD:
- Initial dose: 40 mg/day (once daily or divided into 2 doses). May increase to 80 mg/day after at least 7 days. May increase to 100 mg/day after 2-4 weeks if needed.
- Doses above 80 mg/day are not recommended in adults.
Hepatic Impairment:
- Moderate impairment (Child-Pugh Class B): Reduce dose by 50%.
- Severe impairment (Child-Pugh Class C): Reduce dose by 75%.
Renal Impairment: Dose adjustment may be needed in ESRD patients.
Side effects
Common Adverse Reactions in Children & Adolescents (≥5% and at least twice placebo):
- Nausea
- Vomiting
- Fatigue
- Decreased appetite
- Abdominal pain
- Somnolence
Common Adverse Reactions in Adults:
- Constipation
- Dry mouth
- Nausea
- Decreased appetite
- Dizziness
- Urinary hesitation
- Erectile dysfunction
Serious Adverse Reactions:
- Suicidal ideation in children and adolescents (0.4% of patients)
- Severe liver damage (rare)
- Increased heart rate and blood pressure
- Psychotic or manic symptoms (rare)
Use in pregnancy
[CONSULT YOUR DOCTOR] Insufficient safety data on atomoxetine use during pregnancy (Category C). Animal studies have shown fetal risk. Use only if potential benefit justifies the risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Serious Precautions:
- Suicide risk: Atomoxetine increases the risk of suicidal ideation in children and adolescents. Close monitoring is required during initiation and dose changes.
- Liver damage: Inform your doctor immediately if you experience signs of liver problems (itching, right upper abdominal pain, dark urine, yellow skin/eyes).
- Cardiac risk: Caution in patients with heart problems, heart defects, or high blood pressure.
- Psychiatric symptoms: Inform your doctor if you develop new psychotic or manic symptoms.
- Driving and machinery: Do not drive or operate hazardous machinery until you know how atomoxetine affects you.
- Growth and weight monitoring: Monitor height and weight in children during treatment.
- Do not stop suddenly: Do not stop taking the medication without talking to your doctor first.
Overdose effects
There is no specific antidote for atomoxetine overdose. Symptomatic and supportive treatment is recommended. Overdose may cause nausea, vomiting, somnolence, dizziness, and tachycardia.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.