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Syntocin

5IU/mlRx
Generic: Oxytocin

৳ 10.50/unit

Pack: ৳ 10.50

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At a glance

Oxytocin is a hormone and medication used for induction of labor, stimulation of uterine contractions, prevention and treatment of postpartum hemorrhage and stimulation of lactation.

Indications
  • Induction of labor
  • Stimulation of uterine contractions
  • Prevention and treatment of secondary postpartum hemorrhage
  • Adherent placenta
  • Stimulation of lactation
  • Treatment of incomplete abortion (to prevent secondary hemorrhage)
Pharmacology

Oxytocin binds to specific receptors in uterine smooth muscle to increase intracellular calcium, activating myosin light chain kinase to cause uterine contractions. It also increases local prostaglandin production which further stimulates contraction.

Dosage

Labor Induction (IV):

  • 0.5-1 mUnit/min (initial); titrate 1-2 mUnit/min q15-60min until contraction pattern similar to normal labor (usually 6 mUnit/min)
  • Decrease dose after desired frequency reached and labor progressed to 5-6 cm dilation

Postpartum Hemorrhage (IV): 10-40 units (max 40 units) in 1000 mL nonhydrating IV solution

Incomplete Abortion (IV): 10-20 mUnit/min; not to exceed 30 units/12 hr

IM: 2-5 IU (postpartum); 2 IU (lactation); 2-5 IU every 30-60 min (incomplete abortion)

Side effects

Common Side Effects:

  • Vomiting
  • Headache
  • Uterine contractions
  • Nausea
  • Uterine hypertonicity, spasm, titanic contraction or uterine rupture
  • Water intoxication (with convulsions and coma)
  • Cardiac arrhythmias
  • Anaphylactic reaction
Use in pregnancy

Use in Pregnancy: Oxytocin is safe during pregnancy; low or no risk to fetus.

Pregnancy Category: A — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Uterine sensitivity varies; use lowest effective dose
  • Monitor fetal heart rate and maternal blood pressure
  • Caution if uterine or cervical scars exist
  • Caution while driving (contractions may begin)
Overdose effects

Overdose: Violent uterine contractions, fetal bradycardia, arrhythmias, tissue laceration, uterine rupture, fetal or maternal death; discontinue infusion and induce tocolysis.

Storage conditions

Store at 2-8°C, in dark and frost-free place; keep out of reach of children.

Oxytocin — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.