oshudhkosh

Tazopen 2.252gm+0.25gm

Rx
Dosage form:
Injection
Pack size:
Injection

৳ 550/unit

Pack: ৳ 550

At a glance

Piperacillin + Tazobactam — brands, prices, indication, dosage and side effects available in Bangladesh.

Description

Piperacillin + Tazobactam is a combination of two antibiotics. It is used to treat various types of bacterial infections. It fights against the infection by killing the microorganisms. Piperacillin + Tazobactam is generally administered by a healthcare professional and should not be self-administered. Depending on the severity of your underlying illness, your doctor will decide the precise dose and schedule as per which this injection is to be given. It is strictly advised to be used as per the doctor's prescription. Some of the common side effects of this medicine include nausea, vomiting, diarrhea, and rash. Additionally, you may notice some injection site reactions like pain, swelling, or redness. You should consult your doctor if these side effects do not get better with time and persist for a longer duration. Before using the medicine, you should tell your doctor if you are allergic to any antibiotics or have any kidney or liver problems. Your doctor may change the dose or prescribe a different medicine. This medicine is generally considered safe to use during pregnancy and breastfeeding if used under a doctor's supervision. Piperacillin + Tazobactam is a combination of two medicines: Piperacillin and Tazobactum. Piperacillin is an antibiotic. It works by preventing the formation of the bacterial protective covering which is essential for the survival of bacteria. Tazobactum is a beta-lactamase inhibitor which reduces resistance and enhances the activity of Piperacillin against bacteria.

Indications

• Bacterial infections

Mechanism of action

Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria.

Dosage

Adult Dose: Intravenous Nosocomial pneumonia Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 6 hrly for 5-14 days by infusion over 30 min. When used empirically, combination w/ aminoglycoside or antipseudomonal fluoroquinolone is recommended. Empiric therapy for febrile neutropenic patients Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 6 hrly for 5-14 days by infusion over 30 min. Complicated intra-abdominal infections Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 8 hrly for 5-14 days by infusion over 30 min. Complicated urinary tract infections; Skin and soft tissue infections Adult: Each vial contains 4.5 g (piperacillin 4 g and tazobactam 0.5 g): 4.5 g 8 hrly for 5-14 days by infusion over 30 min. Child Dose: Intravenous Child: Usually 12 yr Same as adult dose. Empiric therapy for febrile neutropenic patients Child: 2-12 yr 90 mg/kg (piperacillin 80 mg/kg and tazobactam 10 mg/kg) 6 hrly for 5-14 days by infusion over 30 min. Max: 4.5 g per dose; >12 yr Same as adult dose. Complicated intra-abdominal infections Child: 2-12 yr 112.5 mg/kg (piperacillin 100 mg and tazobactam 12.5 mg) 8 hrly for 5-14 days by infusion over 30 min. Max: 4.5 g per dose. Renal Dose: Renal impairment: Haemodialysis patients: 2.25 g 12 hrly; additional dose of 0.75 g after each dialysis session. CAPD: 2.25 g 12 hrly. CrCl (ml/min) Dosage Recommendation <20 2.25 g 8 hrly. 20-40 2.25 g 6 hrly.

Administration

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Side effects

Common: • Nausea • Vomiting • Diarrhea • Rash • Allergic reaction

Precautions & warnings

[CONSULT YOUR DOCTOR] It is not known whether Piperacillin + Tazobactam alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. You have been prescribed this combination medicine to treat bacterial infections even if they have developed resistance. Finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat. Diarrhea may occur as a side effect. Taking probiotics along with Piperacillin + Tazobactam may help. Talk to your doctor if you notice bloody stools or develop abdominal cramps. Stop taking Piperacillin + Tazobactam and inform your doctor immediately if you develop an itchy rash, swelling of the face, throat or tongue or breathing difficulties while taking it.

Contraindications

Hypersensitivity.

Drug interactions

Interacts w/ high doses of heparin, oral anticoagulants or other drugs that affect blood coagulation or thrombocyte function. Prolongs the neuromuscular blockade of vecuronium and non-depolarising muscle relaxants. Prolongs half-lives w/ probenecid. Increased risk of methotrexate toxicity.

Food interactions

[SAFE] Consuming alcohol with Piperacillin + Tazobactam does not cause any harmful side effects.

Use in pregnancy

[SAFE IF PRESCRIBED] Piperacillin + Tazobactam is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

Use in lactation

[SAFE IF PRESCRIBED] Piperacillin + Tazobactam is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

Renal / hepatic impairment

[CAUTION] Piperacillin + Tazobactam should be used with caution in patients with kidney disease. Dose adjustment of Piperacillin + Tazobactam may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Piperacillin + Tazobactam is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Piperacillin + Tazobactam may not be needed in these patients. Please consult your doctor.

Common questions

Scar on face due to bacterial infections Pic is not clear, plz visit for proper opinion I have a history of recurring yeast and bacterial vaginosis infections. Tab metrogyl 500 mg twice a day x 5 days and tab fluconazole 150 mg three doses alternate days I suffering from bacterial infections in my shaving area or too much acne problem. Fudic cream twice a day My child verry high cough and fever in cold sesion try to much doctor but result is no . It&#x27;s will be countiue cough and fever it&#x27;s good to be only antiboitic Antibiotics are required if bacterial infections. Consult child specialist What are use mega-cv dry syrup Child are not drinking milk Mega CV is an antibiotic used to treat bacterial infections Sir which medication can we use to fast healing the wound such as minor cut,bacterial infections just apply Neomycin cream locally I get infections around my private parts and also near my toes It&#x27;s basically fungus or bacterial infection Dear Mr PATIENT need to check your lesions before prescribing any medications, post a high quality image of the lesion with a good resolution.

⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.