Tetracomb
RxAt a glance
Gramicidin + Neomycin Sulphate + Nystatin + Triamcinolone Acetonide Topical is used for infected eczema and skin infections.
Indications
- Infected eczema
- Atopic eczema
- Contact eczema
- Infantile eczema
- Otitis externa
- Anogenital pruritus
- Nummular eczema
- Seborrhoeic or flexural eczema
- Neurodermatitis
- Psoriasis
- Cutaneous candidiasis
Pharmacology
Triamcinolone is a fluorinated corticosteroid with anti-inflammatory, antipruritic and anti-allergic actions. Nystatin, a polyene antifungal antibiotic, binds to ergosterol and interferes with the permeability of cell membrane of susceptible fungi. Neomycin is an aminoglycoside, often used topically in the infections against susceptible staphylococci and other organisms. Gramicidin is active against many Gram-positive bacteria. Used together, this combination provides a wide coverage against gram-positive, gram-negative bacteria and yeast.
Dosage
Adult Dose:
- As cream/ointment: Apply sparingly to the affected area 2-3 times daily
- Elderly: Use sparingly for short periods of time
Child Dose:
- As cream/ointment: Apply sparingly to the affected area 2-3 times daily
- Under 1 year: Not recommended
* Use as directed by the registered physician
Side effects
Common Side Effects:
- Burning
- Itching
- Redness
- Skin rash
With prolonged use:
- Sensitivity reactions
- Impaired wound healing
- Thinning of skin
- Striae
- Telangiectasia
- Hirsutism
- HPA axis suppression
- Cushing's syndrome
Use in pregnancy
Use in Pregnancy: FDA has not yet classified the drug into a specified pregnancy category.
Pregnancy Category: NA — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Caution in patients with established hearing loss
- Avoid occlusive dressing and prolonged or recurrent use
- Avoid contact with eyes or mucous membranes
- If no clinical improvement after 7 days, discontinue use
- Limit use to 5 days if used on face or children under 1 year
- Use with caution on inflamed or damaged skin
Overdose effects
Overdose: Overdose is unlikely when used as directed. Excessive use may cause skin irritation.
Storage conditions
Storage: Store at room temperature (15°-30°C), do not freeze, keep away from heat and light.