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Tetracycline Hydrochloride is an antibiotic medicine used to treat bacterial infections in your body. It is effective in some infections of the lungs, urinary tract, eyes, and others. It kills bacteria, which helps to improve your symptoms and cure the infection. Tetracycline Hydrochloride is also used to treat many sexually transmitted diseases. It should be taken on an empty stomach. You should take it regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Taking it at the same time every day will help you to remember to take it. The dose will depend on what you are being treated for, but you should always complete a full course of this antibiotic as prescribed by your doctor. Do not stop taking it until you have finished, even when you feel better. If you stop taking it early, some bacteria may survive and the infection may come back. Commonly seen side effects seen with this medicine include vomiting, nausea, diarrhea, and skin reaction on exposure to sunlight (photosensitivity). Avoid excessive sun exposure and use sunscreen and protective clothing when outdoors. These are usually temporary and subside with the completion of treatment. Consult your doctor if you find these side effects bother or worry you. Inform your doctor if you have any previous history of allergy to any antibiotic or liver or kidney problems before taking this medicine. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant or breastfeeding women should consult their doctor before using it. Tetracycline Hydrochloride is an antibiotic. It stops bacterial growth by preventing synthesis of essential proteins required by bacteria to carry out vital functions.

• Bacterial infections

Tetracycline exhibits its bacteriostatic action by reversibly binding to the 30S subunits of the ribosome, thus preventing protein synthesis and arresting cell growth. It has a broad spectrum of antimicrobial activity including Chlamydiaceae, Mycoplasma spp., Rickettsia spp., spirochaetes, many aerobic and anaerobic gm+ve and gm-ve pathogenic bacteria and some protozoa.

Adult Dose: Oral Susceptible infections Adult: 250-500 mg 6 hrly. Max: 4 g/day. Acne Adult: 250-500 mg daily, in divided doses, for at least 3 mth. Syphilis Adult: 500 mg 4 times daily for 15 days. Gonorrhoea Adult: 500 mg 4 times daily for 7 days. Vibrio Cholera Adult: 500 mg 4 times daily for 3 days Brucellosis Adult: 500 mg 4 times daily for 3 wk in combination w/ streptomycin. Hepatic impairment: Max: 1 g daily. Child Dose: Oral Children : 8 y: 25–50 mg/kg/day q6h not to exceed 3 g/day Renal Dose: Renal impairment CrCl 50-80 mL/min: Dose frequency q8-12hr CrCl 10-50 mL/min: Dose frequency q12-24hr CrCl <10 mL/min: Dose frequency q24hr

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Tetracycline Hydrochloride is to be taken empty stomach.

Common: • Photosensitivity • Vomiting • Nausea • Diarrhea

[SAFE] Tetracycline Hydrochloride does not usually affect your ability to drive. Your doctor has prescribed Tetracycline Hydrochloride to cure your infection and improve symptoms. It should be taken on an empty stomach. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat. Do not take antacids or medicines containing zinc or iron at least 2 hours before or 6 hours after taking Tetracycline Hydrochloride. Discontinue Tetracycline Hydrochloride and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. It may cause dizziness. Don't drive or do anything that requires mental focus until you know how Tetracycline Hydrochloride affects you. Inform your doctor if you are pregnant, planning to conceive or breastfeeding.

Hypersensitivity; pregnancy, lactation, children; renal impairment.

Impaired absorption w/ antacids containing divalent and trivalent cations (e.g. Al, Ca, Mg), Fe, Zn and Na bicarbonate preparations, kaolin-pectin, bismuth subsalicylate, sucralfate, strontium ranelate, colestipol and colestyramine. May interfere w/ the bactericidal action of penicillin. May potentiate the effect of anticoagulants. May decrease efficacy of oral contraceptives. Nephrotoxic effects may be exacerbated by diuretics or other nephrotoxic drugs. May increase the hypoglycaemic effect of insulin and sulfonylureas in patients w/ DM. May increase toxic effects of ergot alkaloids and methotrexate. Potentially Fatal: Concurrent methoxyflurane may result to fatal renal toxicity. Increased risk of benign intracranial HTN w/ vit A or retinoids (e.g. acitretin,isotretinoin, tretinoin).

[SAFE] Consuming alcohol with Tetracycline Hydrochloride does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Tetracycline Hydrochloride is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[SAFE IF PRESCRIBED] Tetracycline Hydrochloride is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby. Use of Tetracycline Hydrochloride is not harmful in short-term because milk levels are low. Prolonged or repeated use may cause staining of babies dental enamel or bone deposition of Tetracycline Hydrochloride.

[CAUTION] Tetracycline Hydrochloride should be used with caution in patients with kidney disease. Dose adjustment of Tetracycline Hydrochloride may be needed. Please consult your doctor. Use of Tetracycline Hydrochloride is not recommended in patients with severe kidney disease. [CAUTION] Tetracycline Hydrochloride should be used with caution in patients with liver disease. Dose adjustment of Tetracycline Hydrochloride may be needed. Please consult your doctor.

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