৳ 70.05/unit
Pack: ৳ 70.05
৳ 70.05/unit
Pack: ৳ 70.05
At a glance
Thiopental Sodium is an ultrashort-acting barbiturate general anesthetic used for induction of anesthesia, brief surgical procedures, and control of convulsive states.
Indications
- Induction of anesthesia (brief procedures)
- Induction prior to other anesthetics
- Supplement to regional anesthesia
- Control of convulsive states during inhalation anesthesia
- Reduction of increased intracranial pressure in neurosurgical patients
- Narcoanalysis and narcosynthesis in psychiatric disorders
Pharmacology
Thiopental Sodium binds to the GABAA receptor, increasing Cl- ionophore opening duration, prolonging GABA's inhibitory effect in the thalamus. It produces hypnosis within 30-40 seconds of IV injection and may accumulate in fatty tissue for prolonged effects.
Dosage
Adult Dose (IV):
- Induction of anesthesia: 100-150 mg (2.5% solution) over 10-15 seconds; repeat 100-150 mg after 1 minute if needed; max 500 mg (250 mg in pregnancy)
- Convulsive states: 75-125 mg (2.5% solution)
- Increased intracranial pressure: 1.5-3.5 mg/kg intermittent bolus (with adequate ventilation)
Pediatric Dose (IV):
- Induction: 2-7 mg/kg over 10-15 seconds; repeat after 1 minute if needed (max 7 mg/kg)
- Convulsive states: 5 mg/kg slow IV; neonates: 2.5 mg/kg/hr IV infusion; >1 month: 2-8 mg/kg/hr
Side effects
Common Side Effects:
- Respiratory depression
- Myocardial depression, cardiac arrhythmias
- Prolonged somnolence and recovery
- Hypotension, tachycardia
- Sneezing, coughing, bronchospasm, laryngospasm
- Shivering, injection site reactions
Serious (Rare):
- Anaphylactic reactions (urticaria, bronchospasm, vasodilation, edema)
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; use only if clearly needed; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in severe respiratory embarrassment, status asthmaticus, porphyria
- Caution in severe cardiovascular disease, hypotension, shock
- Caution in hepatic/renal disease, myxedema, myasthenia gravis
- Habit-forming potential
Overdose effects
Overdose from too rapid or repeated administration may cause severe hypotension, apnea, laryngospasm; discontinue drug and provide supportive treatment.
Storage conditions
Store at 15-30°C; prepare fresh solution and use immediately; discard unused portions; keep out of reach of children.