৳ 2,305/unit
Pack: ৳ 2,305
৳ 2,305/unit
Pack: ৳ 2,305
At a glance
Insulin Glargine is a long-acting human insulin analog used to improve glycemic control in adults and children with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
Indications
- Type 1 diabetes mellitus in adults and children
- Type 2 diabetes mellitus in adults
Pharmacology
Insulin Glargine is a recombinant human insulin analog that is long-acting (up to 24 hours). Its primary function is regulation of glucose metabolism. Insulin and its analogues lower blood glucose by stimulating peripheral glucose uptake (primarily by skeletal muscle and fat) and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis and enhances protein synthesis.
Dosage
Adult Dose (Subcutaneous):
- Type 1 Diabetes: Recommended starting dose: approximately one-third of total daily insulin requirements; short-acting premeal insulin used for remainder
- Type 2 Diabetes (insulin-naïve): 10 units (or 0.2 units/kg) once daily
- Conversion from other insulins: Once-daily NPH: same dose; Twice-daily NPH: 80% of total NPH dose
- Once daily at any time (preferably same time); relatively constant glucose-lowering profile over 24 hours
Child Dose (Type 1, ≥6 years): Approximately one-third of total daily insulin requirements; adolescents <1.2 units/kg/day during growth spurts
Side effects
Side Effects:
- Hypoglycemia
- Allergic reactions
- Injection site reactions
- Lipodystrophy
- Pruritus
- Rash
Use in pregnancy
Use in Pregnancy: Category C; use only if potential benefit justifies potential risk to fetus; animal studies have shown harmful effects.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Renal or hepatic impairment may require dose reduction
- Blood glucose should be monitored in all patients treated with insulin
- Insulin regimens should be modified cautiously and only under medical supervision
- Insulin Glargine must not be diluted or mixed with any other insulin or solution
- Do not administer IV or via insulin pump (severe hypoglycemia can occur)
Overdose effects
Overdose: May result in hypoglycemia; mild episodes treated with oral carbohydrates; severe hypoglycemia treated with parenteral glucose or glucagon injections; adjustments in drug dosage, meal patterns, or exercise may be needed.
Storage conditions
Store at 2°C to 8°C in refrigerator; do not freeze; protect from light.