৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Paracetamol + Tramadol Hydrochloride is a combination pain reliever used for the short-term (5 days or less) management of moderate to moderately severe pain including muscle ache, back pain, joint pain, menstrual cramps, and toothache.
Indications
- Moderate to moderately severe pain
- Muscle ache
- Back pain
- Joint pain
- Menstrual cramps
- Toothache
Pharmacology
Tramadol binds to μ-opioid receptors and weakly inhibits norepinephrine and serotonin reuptake, blocking pain signal transmission to the brain. Paracetamol increases pain threshold by inhibiting prostaglandin synthesis in the CNS. Together they provide faster and longer-lasting pain relief.
Dosage
Adult Dose (Oral):
- Moderate to moderately severe pain: 1-2 tablets every 6 hours; max 8 tablets/day
- Short-term (5 days or less) management of acute pain: 2 tablets every 4-6 hours; max 8 tablets/day
- CrCl 10-30 mL/min: Increase dosing interval to 12 hours
- CrCl <10 mL/min: Not recommended
- Hepatic impairment: Moderate: Increase dosing interval; Severe: Contraindicated
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Constipation
- Weakness
- Dizziness
- Dry mouth
- Drowsiness
- Hyperhidrosis
- Skin rash
- Anorexia
- Anxiety
- Insomnia
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; limited human studies and animal studies show harmful effects. Doctor will weigh benefits and risks before prescribing.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May impair ability to drive or operate machinery; do not drive if drowsy or blurred vision occurs
- Use only for severe acute pain for not more than 5 days; prolonged use may cause dependence
- Avoid alcohol
- Do not use with other tramadol or paracetamol-containing products
- Caution with tranquilizers, hypnotics, or other opioid analgesics
- Caution in epilepsy
Overdose effects
Overdose may cause nausea, vomiting, abdominal pain, drowsiness, convulsions, respiratory depression, hepatic or renal damage. In case of overdose, tell your doctor immediately.
Storage conditions
Store in a cool and dry place; do not freeze; keep out of reach of children.