৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Tramadol Hydrochloride is a pain relieving medicine used to manage persistent, moderate to severe chronic pain that requires continuous, around-the-clock treatment.
Indications
- Moderate to severe pain
- Postoperative pain
- Colic and spastic pain
- Cancer pain
- Joint pain
- Neck and back pain
- Pain associated with osteoporosis
Pharmacology
Tramadol inhibits the reuptake of serotonin and noradrenaline, modifying the transmission of pain impulses by activating descending serotonergic and noradrenergic pathways. Analgesic effects are mediated via mu-opioid receptor stimulation and indirect modulation of central monoaminergic inhibitory pathways.
Dosage
Adult Dose (Oral):
- Immediate release: 50-100 mg every 4-6 hours as needed; max 400 mg/day
- Extended release: 100 mg once daily initially; increase by 100 mg/day every 5 days; max 300 mg/day
Parenteral:
- IM/IV: 50-100 mg every 4-6 hours
Renal impairment: CrCl 10-30: increase dosing interval to 12 hours; CrCl <10: contraindicated
Side effects
Common Side Effects:
- Dizziness
- Sleepiness
- Vomiting
- Nausea
- Constipation
- Injection site reactions
- Headache
- Fatigue
- Dry mouth
- Sweating
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect ability to drive or operate machinery
- Use only for severe acute pain for not more than 5 days
- Prolonged use may result in physical and psychological dependence
- Take with food to avoid upset stomach
- Dose adjustment may be needed in liver or kidney disease
Overdose effects
Symptoms: Respiratory depression, drowsiness, convulsions.
Treatment: Supportive; naloxone may be used.
Storage conditions
Store below 30°C, away from light and moisture; keep out of reach of children.