৳ 2,750/unit
Pack: ৳ 2,750
৳ 2,750/unit
Pack: ৳ 2,750
At a glance
Insulin Degludec is a long-acting human insulin analog used to improve glycemic control in patients 1 year of age and older with diabetes mellitus.
Indications
- Improvement of glycemic control in patients 1 year of age and older with diabetes mellitus
Pharmacology
The primary activity of insulin, including Insulin Degludec, is regulation of glucose metabolism. Insulin and its analogues lower blood glucose by stimulating peripheral glucose uptake (especially by skeletal muscle and fat) and by inhibiting hepatic glucose production. Insulin also inhibits lipolysis and proteolysis and enhances protein synthesis. Insulin Degludec forms multihexamers when injected into subcutaneous tissue, providing slow absorption and albumin binding for prolonged action.
Dosage
Adult Dose (Subcutaneous):
- Type 2 Diabetes: Recommended daily starting dose: 10 units, followed by individual dosage adjustments
- Type 1 Diabetes: One third to one half of the total daily insulin dose; general rule: 0.2-0.4 units/kg for insulin-naïve patients
- Once-daily at any time (preferably same time every day); minimum 8 hours between injections
- Conversion from other insulins: Start at same unit dose
- Dose adjustments: 3-4 days between increases; based on metabolic needs, blood glucose monitoring, glycemic control goal
Child Dose: Not indicated for use in pediatric population under 18 years
Side effects
Side Effects:
- Nasopharyngitis
- Severe hypoglycemic episode
- Upper respiratory tract infection
- Headache
- Diarrhea
- Sinusitis
- Gastroenteritis
- Injection site reactions
- Peripheral edema
Use in pregnancy
Use in Pregnancy: No clinical experience from well-controlled studies; animal studies show no differences in embryotoxicity and teratogenicity; use only if potential benefits justify potential risks to fetus.
Precautions & warnings
Precautions:
- Hypoglycemia: Omission of meal or unplanned strenuous exercise may lead to hypoglycemia
- Hyperglycemia: Administration of rapid-acting insulin recommended in situations with severe hyperglycemia
- Eye disorder: Intensification of insulin therapy with abrupt improvement may be associated with temporary worsening of diabetic retinopathy
- Avoidance of accidental mix-ups: Always check insulin label before each injection
- Concomitant illness affecting kidney, liver, adrenal, pituitary or thyroid gland may require changes in insulin dose
Overdose effects
Overdose: Excess insulin relative to food intake or energy expenditure may lead to severe and sometimes prolonged life-threatening hypoglycemia; mild episodes treated with oral glucose; severe episodes (coma, seizure, neurologic impairment) treated with IM/SC glucagon or IV glucose.
Storage conditions
Store in refrigerator at 2°C-8°C; do not freeze; protect from light.