৳ 35.11/unit
Pack: ৳ 351.10
৳ 35.11/unit
Pack: ৳ 351.10
At a glance
Oxcarbazepine is an antiepileptic drug used for partial seizures. It blocks voltage-sensitive sodium channels to stabilize hyperexcited neuronal membranes and prevent seizure spread.
Indications
- Partial seizures (Adults: monotherapy or adjunctive therapy)
- Partial seizures (Children 4-16 years: monotherapy; 2-16 years: adjunctive therapy)
Pharmacology
Oxcarbazepine and its active metabolite MHD block voltage-sensitive sodium channels to stabilize neuronal membranes, inhibit repetitive neuronal firing and reduce synaptic impulse propagation, preventing seizure spread.
Dosage
Adult Dose (Oral):
- Adjunctive: 300 mg twice daily (initial); increase by 600 mg/day weekly; max 1200 mg/day
- Monotherapy (converting from other AED): 300 mg twice daily (initial); increase by 600 mg/day weekly; max 2400 mg/day
- Monotherapy (AED-naive): 300 mg twice daily (initial); increase by 300 mg/day every 3 days; up to 1200 mg/day
Renal Dose (CrCl <30): Reduce to 50% of usual dose
Side effects
Common Side Effects:
- Dizziness
- Diplopia
- Headache
- Nystagmus
- Abnormal gait
- Nausea
- Vomiting
- Abdominal pain
- Rash
- Hyponatremia
Use in pregnancy
Use in Pregnancy: Oxcarbazepine may be unsafe during pregnancy; animal studies show evidence of fetal harm.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Monitor sodium levels (hyponatremia)
- Caution in patients with hypersensitivity to carbamazepine
- Caution while driving
- Avoid alcohol
- Inform doctor if suicidal thoughts or mood changes occur
Overdose effects
Overdose: Drowsiness, dizziness, diplopia, ataxia, hyponatremia; symptomatic treatment.
Storage conditions
Store at temperature not exceeding 30°C in a dry place; protect from light and moisture; keep out of reach of children.