U (10)
25mcg+62.5mcg+100mcgRx৳ 90/unit
Pack: ৳ 900
৳ 90/unit
Pack: ৳ 900
At a glance
Vilanterol Trifenatate + Fluticasone Furoate + Umeclidinium Bromide is indicated for the maintenance treatment of patients with chronic obstructive pulmonary disease (COPD) and the maintenance treatment of asthma in patients aged 18 years and older.
Indications
- Chronic obstructive pulmonary disease (COPD)
- Asthma (18 years and older)
Pharmacology
This capsule is an inhalation powder drug product. Vilanterol is a LABA that stimulates intracellular adenyl cyclase, increasing cyclic AMP, which relaxes bronchial smooth muscle. Fluticasone furoate is an ICS with a wide range of actions on multiple cell types and mediators involved in inflammation. Umeclidinium is a LAMA that inhibits M3 receptor, leading to bronchodilation.
Dosage
Adult Dose (Inhalation):
- COPD maintenance: 1 inhalation capsule once daily
- Asthma maintenance: 1 inhalation capsule once daily
- Use at the same time every day, not more than once every 24 hours
Side effects
Common Side Effects:
- Upper respiratory tract infection
- Pneumonia
- Bronchitis
- Oral candidiasis
- Headache
- Back pain
- Arthralgia
- Influenza
- Sinusitis
- Pharyngitis
- Rhinitis
- Dysgeusia
- Constipation
- Urinary tract infection
- Diarrhea
- Gastroenteritis
- Oropharyngeal pain
- Cough
- Dysphonia
Use in pregnancy
Use in Pregnancy: Insufficient data on use in pregnant women.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- LABA monotherapy increases risk of serious asthma-related events
- Do not initiate in acutely deteriorating COPD or asthma
- Do not use to treat acute symptoms
- Do not use in combination with additional LABA-containing therapy
- Candida albicans infection of mouth and pharynx may occur; monitor periodically
- Increased risk of pneumonia in patients with COPD; monitor for signs and symptoms
- If paradoxical bronchospasm occurs, discontinue and institute alternative therapy
- Use with caution in patients with cardiovascular disorders
- Worsening of urinary retention may occur; caution in prostatic hyperplasia or bladder-neck obstruction
- Use with caution in patients with convulsive disorders, thyrotoxicosis, diabetes mellitus, and ketoacidosis
Overdose effects
Symptoms: No data available from clinical trials on overdose.
Treatment: Supportive care.
Storage conditions
Avoid storage in direct sunlight or heat. Store in a cool & dry place. Keep away from eyes. Keep out of reach of children.