Unifarin 1

Warfarin Sodium is an oral anticoagulant which helps prevent the formation of harmful blood clots in the legs, lungs, brain and heart. It is used for deep vein thrombosis, pulmonary embolism and stroke prevention. Warfarin Sodium should be taken as advised by the doctor. You may take it with or without food but it is better to take it at a fixed time. This medicine should not be stopped abruptly without consulting the doctor. You should take this medicine regularly to get the most benefit, even if you feel fine. It is preventing future harm. Use of this medicine may increase your risk of bleeding. Let your doctor know immediately if you see pinpoint rash or blood in your vomits, urine, or stool. If you are going under any surgery or dental treatment then you may need to stop this medicine for some time but only after consulting with your doctor. Before taking it, you must inform doctor if you are suffering from any kidney or liver disease. Also let your doctor know if you are pregnant or breastfeeding and about all the other medications that you are taking regularly. Warfarin Sodium is an anticoagulant. It works by preventing the formation of harmful blood clots. Although it does not dissolve the existing blood clots, it prevents them from growing larger and causing blockages in the blood vessels.

• Deep vein thrombosis • Pulmonary embolism • Stroke prevention

Warfarin inhibits synthesis of vit K-dependent coagulation factors VII, IX, X and II and anticoagulant protein C and its cofactor protein S. No effects on established thrombus but further extension of the clot can be prevented. Secondary embolic phenomena are avoided.

Adult Dose: Oral Treatment and prophylaxis of venous thromboembolism, Stroke & Thromboembolism, Post-Myocardial Infarction Adult: Initially, 2-5 mg qDay for 2 days, OR 10 mg daily for 2 days in healthy individuals Initiate warfarin on day 1 or 2 of LMWH or unfractionated heparin therapy and overlap until desired INR, THEN discontinue heparin Check INR after 2 days and adjust dose according to results Usual maintenance dose: 2-10 mg daily. Elderly: Anticoagulation Lower doses required to produce therapeutic level of anticoagulation Initial: <5 mg PO qDay Maintenance: 2-5 mg PO qDay Hepatic impairment: Severe: Avoid. Child Dose: Thrombosis Prevention/treatment: If baseline INR is 1.0-1.3, administer loading dose of 0.1-0.2 mg/kg PO qDay × 1 day; check INR on days 2-4 and adjust daily dose to maintain INR between 2.0 and 3.0 (unless valve replacement indicates a higher range) Use 0.1 mg/kg to initiate therapy with liver impairment or in patients who have had a Fontan procedure Typical maintenance dose: 0.09-0.33 mg/kg/day, with infants <12 months old often requiring doses at high end of range

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Warfarin Sodium may be taken with or without food, but it is better to take it at a fixed time. Avoid Warfarin Sodium with Vitamin K rich food such as spinach, collards, broccoli, spring onions, cucumber and dried basil.

If you miss a dose of Warfarin Sodium, skip it and continue with your normal schedule. Do not double the dose.

Hemorrhage is the principal adverse effect of oral anticoagulants. Jaundice, hepatic dysfunction, vasculitis, pancreatitis, nausea, vomiting, diarrhoea, taste perversion, abdominal pain, flatulence, bloating, rash, purpura, erythematous swollen skin patches leading to ecchymosis, pruritus, alopecia, purple discolouration of toes due to cholesterol embolisation, tracheal or tracheobronchial calcification, fever, chills. Unexplained drop in haematocrit, decreased Hb. Rarely, hypersensitivity reactions. Potentially Fatal: Haemorrhage from almost any organ of the body w/ the consequent effects of haematomas as well as anaemia, tissue necrosis and/or gangrene of skin or other tissues w/ SC infarction.

[SAFE] Warfarin Sodium does not usually affect your ability to drive. Avoid making sudden major changes to your diet during treatment with this medicine. Do not consume alcohol while taking Warfarin Sodium as this may increase its side effects. If you are going to have a surgery or dental treatment, you may be asked to stop taking Warfarin Sodium temporarily. Do not discontinue use without consulting your doctor as this may increase your chances of having another heart attack or stroke.

Patient w/ haemorrhagic tendencies or blood dyscrasias, recent or contemplated surgery of the CNS or eye, those undergoing traumatic surgery resulting in large open surfaces, overt bleeding or active ulceration involving the GI, genitourinary or resp tract, cerebrovascular haemorrhage, cerebral aneurysms, dissecting aorta, pericarditis and pericardial effusions, bacterial endocarditis, threatened abortion, eclampsia, pre-eclampsia, malignant HTN. Unsupervised patients w/ conditions associated w/ potential high level of non-compliance, spinal puncture and other diagnostic or therapeutic procedures w/ potential for uncontrolled bleeding, major regional or lumbar block anaesth. Concomitant use w/ fibrinolytic drugs (e.g. streptokinase, alteplase). Pregnancy.

Cholestatic hepatitis may occur when taken concomitantly w/ ticlopidine. Increased risk of bleeding w/ other anticoagulants (e.g. argatroban, dabigatran, heparin), antiplatelet agents (e.g. aspirin, cilostazol, clopidogrel), NSAIDs (e.g. celecoxib, diclofenac, ibuprofen), serotonin reuptake inhibitors (e.g. citalopram, paroxetine, venlafaxine). Increased INR w/ CYP2C9 (e.g. amiodarone, capecitabine, cotrimoxazole), CYP1A2 (e.g. aciclovir, allopurinol, ciprofloxacin) and CYP3A4 (e.g. alprazolam, amlodipine, atorvastatin) inhibitors. Decreased INR w/ CYP2C9, CYP1A2 and CYP3A4 inducers. Potentially Fatal: Increased risk of bleeding w/ fibrinolytic drugs (e.g. streptokinase and alteplase).

[UNSAFE] It is unsafe to consume alcohol with Warfarin Sodium.

[UNSAFE] Warfarin Sodium is highly unsafe to use during pregnancy. Seek your doctor's advice as studies on pregnant women and animals have shown significant harmful effects to the developing baby.

[SAFE IF PRESCRIBED] Warfarin Sodium is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[SAFE IF PRESCRIBED] Warfarin Sodium is safe to use in patients with kidney disease. No dose adjustment of Warfarin Sodium is recommended. However, talk to your doctor if you have any underlying kidney disease. Regular blood tests are recommended when you are taking this medicine. [CAUTION] Warfarin Sodium should be used with caution in patients with liver disease. Dose adjustment of Warfarin Sodium may be needed. Please consult your doctor.

Deep vein thrombosis , swelling nd painful in both leg. You need to take a surgical consultation Looking for a specialist in Deep vein thrombosis preferably in Kochi See a vascular surgeon In road accident head and small intestine got injured . 15 stiches on head and operation of 1 inch diameter of intestine . Now spo2 level is dropping to 70% after 1 hour of removing oxygen mask Get checked for pulmonary embolism or pneumothorax GE my self v.k tiwari mbbs md i feel the patient information above is there any blood test for diagnosed pulmonary edema and pulmonary embolism Dear Sir There is no specific blood test for diagnosing pulmonary edema and embolism Thrombosis involving both main pulmonary arteries and branches . Sir the patent has been chest pain with thrombosis pulmonary in both arteries n branch So what is the solution n treatment for this patent Need to see you in person.can meet me at medanta.call 9XXXXXX I am suffering from pulmonary embolism. I want to know will i die because of this disease ? What is d extent of your disease My Lungs operation on 2012 april.Trobo Entartectome The Right and left preliminary have Trombus Doctor Remove the trobus.Left side is more.PTINR level For 10 Days 2.2 TO 2.6 Now the days left chest side and Right side is always pain.Ecg checked. Bp.110/80.pulse 76.all relevent medical bloodl test ok.Pl Advice me return email I look have to receive your reply.Thank you.Jwala.m.m.If need I will forward you my all test reports Tab.Asitrom.5.5mg.Atorbrst.20.Fruselac Ds Tab.Caverta Sildinafil Tab.8mg 3 times Every Day.Digoxin.0.25mg. dear Mr Jwala. Your condition is coomplex. Pain after pulmonary embolism may be due to lung infarcts. please discuss with treating cardiologist and pulmonologist I think I have symptoms of dvt(deep vein thrombosis) I have features like deep pain in ankle knees and under feet very warmth compared to body temperature how can I get overcome from that can u pls kindly suggest Do exercises of calf muscles eg Heel raise etc.