৳ 2/unit
Pack: ৳ 20
৳ 2/unit
Pack: ৳ 20
At a glance
Warfarin Sodium is an oral anticoagulant which helps prevent the formation of harmful blood clots in the legs, lungs, brain and heart. It is used for deep vein thrombosis, pulmonary embolism and stroke prevention.
Indications
- Deep vein thrombosis
- Pulmonary embolism
- Stroke prevention
- Prophylaxis and/or treatment of thromboembolic complications associated with atrial fibrillation and/or cardiac valve replacement
- Reduce the risk of death, recurrent myocardial infarction, and thromboembolic events after myocardial infarction
- Transient ischaemic attacks
Pharmacology
Warfarin inhibits synthesis of vit K-dependent coagulation factors VII, IX, X and II and anticoagulant protein C and its cofactor protein S. No effects on established thrombus but further extension of the clot can be prevented.
Dosage
Adult Dose (Oral):
- Initial: 2-5 mg once daily for 2 days, or 10 mg daily for 2 days in healthy individuals
- Initiate warfarin on day 1 or 2 of LMWH or unfractionated heparin therapy and overlap until desired INR
- Check INR after 2 days and adjust dose according to results
- Usual maintenance dose: 2-10 mg daily
- Elderly: Initial <5 mg once daily; maintenance 2-5 mg once daily
- Hepatic impairment: Severe: Avoid
Side effects
Common Side Effects:
- Hemorrhage (principal adverse effect)
- Jaundice
- Hepatic dysfunction
- Vasculitis
- Pancreatitis
- Nausea
- Vomiting
- Diarrhoea
- Taste perversion
- Abdominal pain
- Flatulence
- Rash
- Purpura
- Pruritus
- Alopecia
- Fever
- Chills
Use in pregnancy
Use in Pregnancy: Highly unsafe; do not use during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Does not usually affect ability to drive
- Avoid making sudden major changes to your diet during treatment
- Do not consume alcohol; may increase side effects
- Consult doctor before surgery or dental treatment
- Do not discontinue use without consulting your doctor
Overdose effects
Symptoms: Hemorrhage or a potential bleeding state.
Treatment: Temporary withdrawal of warfarin; if necessary, infusion of fresh-frozen plasma or whole blood; Vitamin K, 5 mg to 10 mg orally or intravenously.
Storage conditions
Do not store above 30°C. Keep away from light and out of the reach of children.