Valex CR 500

Sodium Valproate (valproic acid) is a combination of two medicines used to treat epilepsy, a neurological disorder in which there are recurrent episodes of seizures or fits. It controls the abnormal activity of the brain, relaxes the nerves and hence, prevents seizures or fits. Sodium Valproate (valproic acid) should be taken with food. Your doctor will decide the correct dose for you. This may increase gradually until your condition is stable. This medicine may take several weeks to work but it is important to take it regularly to get the benefit. Do not stop taking it, even if you feel fine unless your doctor advises you to. You may have more seizures, or your bipolar disorder may get worse. The most common side effects of this medicine include nausea, vomiting, loss of appetite, swelling of gums, headache, sleepiness, tremor, hair loss and liver injury. Most side effects wear off, but if they bother you or do not go away, tell your doctor. There may be ways of preventing or reducing these effects. Before taking this medicine, tell your doctor if you have kidney or liver problems, meningitis or depression or suicidal thoughts. Also let your doctor know about all other medications you are using as some may affect, or be affected by, this medicine, including contraceptive pills. If you are pregnant or breastfeeding, Sodium Valproate (valproic acid) can be taken if it is clearly needed but the dose may be adjusted. You should avoid driving or riding a bicycle if this medicine makes you drowsy or dizzy. You may need frequent blood tests to check how you are responding to this medicine. You should avoid alcohol while taking Sodium Valproate (valproic acid), as it may worsen certain side effects. This medicine can also lead to weight gain, eat a healthy balanced diet, avoid snacking with high-calorie food, and exercise regularly. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, or suicidal thoughts or behavior. Sodium Valproate (valproic acid) is a combination of two antiepileptic medicines: Sodium Valproate and Valproic Acid. They work together to control seizures or fits by decreasing the abnormal and excessive activity of the nerve cells in the brain.

• Epilepsy

Valproate is a generic term used to describe valproic acid, its salts and derivatives. It is available in various forms including the sodium salts (valproate semisodium and sodium valproate), the amide derivative (valpromide), or as valproic acid. Valproate is a carboxylic acid anticonvulsant. It has been suggested that its antiepileptic activity is related to increased brain levels of ?-aminobutyric acid (GABA).

Adult Dose: Oral Complex Partial Seizures Indicated as monotherapy and adjunctive therapy for complex partial seizures that occur either in isolation or in association with other types of seizures PO: 10-15 mg/kg/day initially; increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day Simple & Complex Absence Seizures Also indicated for use as sole and adjunctive therapy in the treatment of simple and complex absence seizures, and adjunctively in patients with multiple seizure types that include absence seizures PO: 15 mg/kg/day initially, divided q6-12hr; increase by 5-10 mg/kg/day at weekly intervals; may increase dose up to 60 mg/kg/day Migraine Indicated for prophylaxis of migraine headaches; there is no evidence of use for acute treatment 250 mg PO q12hr; adjust dose based on clinical response, not to exceed 1000 mg/day Bipolar Mania Indicated for treatment of manic episodes associated with bipolar disorder 750 mg/day PO in divided doses; adjust dose as rapidly as possible to desired therapeutic effect; not to exceed 60 mg/kg/day Hepatic impairment Administer lower doses Contraindicated in severe impairment Child Dose: 10 years 250 mg PO q12hr; adjust dose based on clinical response up to 1000 mg/day Renal Dose: Renal impairment No adjustment necessary

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Sodium Valproate (valproic acid) is to be taken with food.

Common: • Nausea • Vomiting • Weight gain • Loss of appetite • Gum swelling • Headache • Sleepiness • Tremor • Hair loss • Liver injury

[UNSAFE] Sodium Valproate (valproic acid) may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Encorate Chrono 500 Tablet CR for treatment and prevention of seizures. Take it at the same time every day to maintain consistent levels in your body. Do not drive or do anything that requires mental focus until you know how Encorate Chrono 500 Tablet CR affects you. Avoid consuming alcohol when taking Encorate Chrono 500 Tablet CR, as it may cause excessive sleepiness or drowsiness. Monitor your weight during the treatment as Encorate Chrono 500 Tablet CR can cause weight gain. Your doctor may monitor Encorate Chrono 500 Tablet CR level, blood counts and liver function regularly throughout your treatment. Inform your doctor if you develop fever, stomach pain, nausea or yellowing of your eyes or skin. Do not take Encorate Chrono 500 Tablet CR if you are pregnant or planning to conceive or breastfeeding. Do not stop taking the medication suddenly without talking to your doctor as it may increase the seizure frequency.

Preexisting or family history of hepatic dysfunction, active liver disease, porphyria; mitochondrial and urea cycle disorders. Hepatic impairment. Pregnancy.

Increased risk of toxicity w/ bupropion. Increased risk of convulsions w/ mefloquine. Increased risk of carnitine deficiency w/ pivmecillinam and pivampicillin. Increased risk of hepatotoxicity and carbamazepine toxicity w/ a decrease in valproic acid levels w/ concurrent carbamazepine. Decreased valproic acid and increased ethosuximide serum levels w/ ethosuximide. Decreased valproic acid levels w/ carbapenems, rifampicin, phenytoin, phenobarbital (or primidone) and antineoplastic drug regimens. Increased valproic acid levels w/ felbamate and aspirin. Increased risk of hepatotoxicity w/ olanzepine. Concurrent use increased phenobarbital, nimodipine, nifedipine, lamotrigine, zidovudine, amitriptyline, nortriptyline and benzodiazepines levels. Concurrent use decreased tigabine and clozapine levels. Increased risk of absence status w/ clonazepam. Increased risk of hyperammonaemia w/ topiramate. Increased free valproic acid concentrations w/ highly protein bound drugs. Potentially Fatal: Concomitant carbapenem is not recommended as this may decrease valproate levels. Avoid concurrent salicylates in childn <3 yr due too risk of hepatotoxicity. Increased risk of hepatotoxicity w/ cosyntropin. Avoid ethanol as this may increase CNS depression.

[UNSAFE] It is unsafe to consume alcohol with Sodium Valproate (valproic acid).

[CONSULT YOUR DOCTOR] Sodium Valproate (valproic acid) is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[SAFE IF PRESCRIBED] Sodium Valproate (valproic acid) is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.

[SAFE IF PRESCRIBED] Sodium Valproate (valproic acid) is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Sodium Valproate (valproic acid) may not be needed in these patients. Please consult your doctor. However, talk to your doctor if you have any underlying kidney disease. [CAUTION] Sodium Valproate (valproic acid) should be used with caution in patients with liver disease. Dose adjustment of Sodium Valproate (valproic acid) may be needed. Please consult your doctor. Use of Sodium Valproate (valproic acid) is not recommended in patients with severe liver disease and active liver disease.

Hello , I am taking encorate chrono 500(2) .I am suffering from epilepsy. Which toothpaste I shall use. you can use BABA RAMDEV Tooth paste Hello , I am taking encorate chrono 500(2) Please advice the best toothpaste I shall use.? Standard ones like Colgate shud do ?? ???? ?????? ?? ?????? ?? ?? ??? encorate Charon 200 500 tablet use krta hu kya iska koi solution h Jisse main completely thk ho jau Epilepsy requires regular treatment with anticonvulsants like encorate chrono for at least 3 years of seizure free period after which medicines may be tapered off unless seizures reappear. At present, there are no other effective treatment options. Hello, I am taking encorate chrono 500(2). Which tablet shall I take when I feel headache. It would be great if you could give me a natural way to solve the problem. Napra 250 mg dos Please suggest substitute of Levipil 500, It causes irratible behavior in my ADHD child also suffering from Epilepsy. He is taking Risperidone 0.75 mg from 2009. He is taking Levipil 500 and Lobazam 10 mg from 11th April 2016. Initially also, Irratibility was there but according to Doctor, it will be ok after few days .try epillex chrono 300 mg bd My wife is 25 yrs old having stress problem, she&#x27;s using encorate chrono 500. We are newly married. Is it makes any side effects to become conceive and future problem. Please, guide me. Divalproex Sodium is a mood stabilizer and should not be taken during pregnancy. It is advisable that you consult regularly with the psychiatrist before planning conception so that patient can be assessed and medicines can be safely withdrawn. Patient on this medicine also needs to have regular liver tests done TAKEN EPTOIN 100-2TAB B.D. & ENCORATE CHRONO 5001 TAB B.D.FOR 10 YRS .LAST SEIZURE OCCURED 4YRS BACK . HOW MANY DAYS I HAVE TO CONTINUE , ANY ALTERNATIVE MED. REQUIRE Medicine can be slowly withdrawn under supervision Can I have Azithral 500 for my throat infection? I am on Valprin Chrono and Frisium for my epilepsy Visit ent specialist instead of starting medicine on your ownThere r different diagnosis for each symptom