৳ 35.14/unit
Pack: ৳ 35.14
৳ 35.14/unit
Pack: ৳ 35.14
At a glance
Bambuterol Hydrochloride is a bronchodilator used to relieve symptoms of asthma and chronic obstructive pulmonary disease (COPD) such as coughing, wheezing and breathlessness.
Indications
- Bronchial asthma
- Chronic bronchitis
- Emphysema
- Other lung diseases where bronchospasm is a complicating factor
Pharmacology
Bambuterol is a prodrug of terbutaline and a long-acting beta2-adrenergic receptor agonist. It predominantly stimulates beta2 receptors, producing relaxation of bronchial smooth muscle, inhibition of release of endogenous spasmogens, inhibition of edema caused by endogenous mediators, and increased mucociliary clearance.
Bambuterol is converted to terbutaline in the blood and acts on beta2 receptors to produce bronchodilation.
Dosage
Adults:
- Initial dose: 10 mg daily (at bedtime)
- Dose increase: May be increased to 20 mg after 1-2 weeks depending on clinical effect
Children (2-5 years): 10 mg (10 ml syrup) daily
Children (6-12 years): 10 mg (10 ml syrup) daily; may be increased to 20 mg if needed
Hepatic Impairment (Severe): Not recommended
Renal Impairment (CrCl <50 mL/min): Initial dose should be halved
Side effects
- Headache
- Palpitations
- Tremor
- Muscle cramp
- Insomnia
- Restlessness
- Fatigue
- Nausea
- Dizziness
Use in pregnancy
[CONSULT YOUR DOCTOR] Bambuterol Hydrochloride may be unsafe during pregnancy (Category C). Animal studies have shown harmful effects on the developing baby. Caution is recommended during the first trimester.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- In severe renal impairment (CrCl <50 mL/min), halve the initial dose
- Caution in patients with history of diabetes, thyroid disease, high blood pressure, heart disease, liver or kidney problems
- Caution in patients with family history of glaucoma
- Monitor serum potassium levels in patients with severe asthma
- Caution during the first trimester of pregnancy
- Caution when driving or operating machinery (may cause dizziness or tremor)
Overdose effects
No case of bambuterol overdose has been reported in humans. Overdose may result in high levels of terbutaline causing headache, anxiety, tremor, nausea, muscle cramps, palpitations, tachycardia, and cardiac arrhythmias. Hyperglycemia and lactacidosis may occur. High doses of beta2-agonists may cause hypokalemia.
Storage conditions
Store below 30°C, away from light and moisture. Keep out of reach of children.