৳ 3/unit
Pack: ৳ 30
৳ 3/unit
Pack: ৳ 30
At a glance
Verapamil Hydrochloride is used to treat angina, high blood pressure and some types of irregular heartbeats (arrhythmia). It works by relaxing blood vessels to lower blood pressure.
Indications
- Hypertension (high blood pressure)
- Angina (heart-related chest pain)
- Arrhythmia
- Supraventricular arrhythmias
- Chronic atrial fibrillation
- Paroxysmal supraventricular tachycardia
- Tardive dyskinesia
Pharmacology
Verapamil inhibits entry of calcium ions into arterial smooth muscle cells as well as the myocytes and conducting tissue. These actions lead to reversal and prevention of coronary artery spasm, reduction in afterload through peripheral vasodilatation and reduction in ventricular rate in patients with chronic atrial flutter or fibrillation.
Dosage
Adult Dose (Oral):
- Hypertension: Immediate release 80 mg every 8 hours initially; maintenance 80-320 mg every 12 hours; Extended release 180 mg/day initially; may increase to 240 mg/day, then by 120 mg/day at weekly intervals; max 480 mg/day
- Angina: Immediate release 80 mg every 8 hours; usual range 80-120 mg every 8 hours; max 480 mg/day
- Chronic atrial fibrillation & paroxysmal supraventricular tachycardia: Immediate release 240-480 mg/day divided every 6-8 hours
- Hepatic impairment: In cirrhosis, reduce dose by 20-50%
Adult Dose (IV):
- 2.5-5 mg IV over 2 minutes; 5-10 mg dose may be repeated after 15-30 minutes
Side effects
Common Side Effects:
- Headache
- Constipation
- Infection
- Dizziness
- Sinus infection
- Flu-like symptoms
- Peripheral edema
- Hypotension
- Bradycardia
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive
- May cause dizziness or sleepiness; do not drive
- Orthostatic hypotension may occur; rise slowly if you have been sitting or lying down
- Avoid alcohol; may worsen side effects
- Contraindicated in severe left ventricular dysfunction, hypotension, sick sinus syndrome, 2nd or 3rd degree AV block
Overdose effects
Symptoms: Hypotension, bradycardia, heart block.
Treatment: Beta-adrenergic stimulation or parenteral administration of calcium solution; verapamil cannot be removed by hemodialysis.
Storage conditions
Do not store above 30°C. Keep away from light and out of the reach of children.