Vinorelbine30mg

Vinorelbine is an anti-cancer medication used in the treatment of breast cancer and non-small cell lung cancer. It is given as an injection by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include nausea, vomiting, weakness, fatigue, and hair loss. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or are taking any medicines to treat infections. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Men are advised to seek guidance and counselling on sperm conservation before taking this therapy. Vinorelbine blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

• Breast cancer • Non-small cell lung cancer

Vinorelbine, a semisynthetic vinblastine derivative, binds to tubulin and inhibits microtubule formation. This disrupts the formation of the mitotic spindle thereby arresting the cell at metaphase.

Adult Dose: Oral Non-small cell lung cancer Adult: 60 mg/m2once wkly for 3 wk, may increase subsequently to 80 mg/m2 once wkly. If neutrophil count is 75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%. Intravenous Non-small cell lung cancer Adult: As single agent: 30 mg/m2 wkly as infusion over 20-30 minutes (after diluting in 125 ml normal saline or glucose 5%) or as slow bolus over 5-10 minutes (after diluting in 20-50 ml normal saline or glucose 5%). Delay subsequent doses if neutrophil count is 75% of liver volume replaced by the tumour): Decrease dose by 1/3. Bilirubin 2.1-3 mg/100 ml: Reduce IV dose by 50%. Bilirubin >3 mg/100 ml: Reduce IV dose by 75%. Cervical cancer Adult: 30 mg/m2/dose days 1 and 8 of a 21-day treatment cycle. Intravenous Breast cancer; Ovarian cancer Adult: 25 mg/m2/dose every 7 days. Hepatic impairment: Dose adjustments may be needed.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Nausea • Vomiting • Weakness • Fatigue • Hair loss • Low blood platelets • Increased liver enzymes • Fever • Anemia (low number of red blood cells) • Bleeding • Constipation

[SAFE] Vinorelbine does not usually affect your ability to drive. Inform your doctor if you have a history of heart problems, vascular problems or low production of blood cells from the bone marrow (myelosupression); liver problems or have had radiotherapy around the liver. Do not take live or attenuated vaccines during therapy and avoid contact with people who receive them. Use two methods of contraception while on this therapy and 3 months after it to avoid pregnancy. Men should not father a child while on this therapy and 3 months post it. They should also seek guidance and counselling on sperm conservation before taking this therapy. Avoid contact with skin, eyes or mucosa as vinorelbine may cause irritation. Thoroughly wash the skin area, in case of skin contact with the medicine. Take vinorelbine preferably with a light meal to reduce nausea. Soft capsule gels of vinorelbine should not be taken with hot fluids, as the medicine may quickly dissolve. Vinorelbine is not recommended in children below 18 years.

Hypersensitivity to vinorelbine or other vinca alkaloids; severe current or recent infection (within last 2 wk); neutropenia; thrombocytopenia; severe hepatic impairment. Intrathecal admin. Do not give concomitantly with radiotherapy if liver is in treatment field. Pregnancy, lactation.

Increased risk of granulocytopenia with cisplatin. Increased risk of neurotoxicity with paclitaxel, itraconazole, ketoconazole. Increased radiosensitising effects with prior or concomitant radiation therapy. Increased pulmonary toxicity with mitomycin. Increased myelotoxicity with zidovudine. Earlier onset and/or an increased severity of side effects with CYP3A inhibitors. Possible increase in vincristine levels with aprepitant. Possible infection with live vaccines.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Vinorelbine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Vinorelbine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Vinorelbine is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Vinorelbine is safe to use in patients with kidney disease. No dose adjustment of Vinorelbine is recommended. However, talk to your doctor if you have any underlying kidney disease. [CAUTION] Vinorelbine should be used with caution in patients with liver disease. Dose adjustment of Vinorelbine may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised while these patients are taking this medicine.

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