Vinstin2mg/vial

Vincristine Sulphate is an anti-cancer medication used in the treatment of breast cancer, non-small cell lung cancer, pancreatic cancer, kidney cancer, blood cancer, multiple myeloma, lymphomas and bone cancer. Vincristine Sulphate is given as an injection into the vein under the supervision of a doctor. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. The most common side effects of this medicine include hair loss, peripheral neuropathy (tingling and numbness of feet and hand), and constipation. This medicine may reduce the number of blood cells (white blood cells) in your blood, thereby, increasing the susceptibility to infections and fever. In some cases, it may also cause kidney disease related to uric acid level. Regular blood tests are required to check your blood cells along with heart, liver, and blood uric acid levels. Many other medicines can affect, or be affected by, this medicine so let your doctor know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. you are suggested to avoid direct contact of medicine with eyes, as it may cause eye irritation. Vincristine Sulphate blocks replication of genetic material (DNA) in the cancer cells. Thus it stops the growth and multiplication of cancer cells.

• Breast cancer • Non-small cell lung cancer • Pancreatic cancer • Kidney cancer • Blood cancer • Multiple myeloma • Lymphomas • Bone cancer

Vincristine arrests cell division at the metaphase stage by inhibiting microtubule formation in the mitotic spindle.

Adult Dose: Intravenous Acute lymphoblastic leukaemia Adult: Usual recommended dosage: 1.4-1.5 mg/m2 once wkly. Max: 2 mg wkly. Subsequent doses may be modified based on clinical and haematological responses and tolerance of the patient. May be used in combination with other drugs. Prescribers should consult published protocols for the dosage, method and sequence of admin. Hepatic impairment: Dose adjustment may be needed. Serum bilirubin >3 mg/100ml: Reduce dose by 50%. Child Dose: Intravenous Acute lymphoblastic leukaemia Child: Usual recommended dosage: 1.5-2 mg/m2 once wkly; for patients ?10 kg: Initiate at 0.05 mg/kg once wkly. Subsequent doses may be modified based on clinical and haematological responses and tolerance of the patient. May be used in combination with other drugs. Prescribers should consult published protocols for the dosage, method and sequence of admin. Renal Dose: Renal Impairment Dose adjustment not necessary

Your doctor or nurse will give you this medicine. Kindly do not self administer.

Common: • Hair loss • Peripheral neuropathy (tingling and numbness of feet and hand) • Constipation

[UNSAFE] Vincristine Sulphate may cause side effects which could affect your ability to drive. Avoid being near people suffering from infections (such as, cold, flu, contagious illnesses), as you may be more susceptible to infections, while on vincristine therapy, because of possibility of leukopenia. Avoid even accidental contamination of eyes with vincristine as it may cause severe irritation. Vincristine may cause acute kidney disease (nephropathy) related to uric acid level. Care should be taken in elderly patients because they are more susceptible to neurotoxic effects of vincristine. In males, vincristine may cause aspermia (lack of semen causing infertility); in females vincristine may cause amenorrhea (absence of menstruation), which may recover after some duration. Tell your doctor if you are or planning to become pregnant or are breastfeeding.

Patients with demyelinating form of Charcot-Marie-Tooth syndrome. Pregnancy and lactation. Intrathecal admin (may be fatal). Patients receiving radiation therapy through ports which include liver.

Decreased digoxin (tablets) and verapamil absorption with antineoplastic regimens. Increased etoposide serum levels with vincristine. Increased toxicity when ganciclovir given with, immediately before or after vincristine. Reduced vincristine metabolism with miconazole. Increased neurotoxicity with isoniazid, itraconazole, voriconazole, posaconazole and nifedipine. Decreased immune response when used concurrently with vaccines. Increased myelotoxicity with zidovudine. Increased risk of thromboembolic complications with tamoxifen. Increased risk of ototoxicity with ototoxic drugs (e.g. platinum-containing antineoplastic agents). Possible risk of earlier onset and/or increased severity of adverse effects with macrolides. Possible increase in vincristine levels with aprepitant. Possible decrease in antiepileptic levels with vincristine, monitor serum antiepileptic levels and effectiveness of chemotherapy. Potentially Fatal: Increased risk of bronchospasm with mitomycin C. Reduced vincristine clearance and increased toxicity with asparaginase, minimise toxicity by giving vincristine 12-24 hr before L-asparaginase admin.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Vincristine Sulphate. Please consult your doctor.

[CONSULT YOUR DOCTOR] Vincristine Sulphate is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Vincristine Sulphate is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Vincristine Sulphate should be used with caution in patients with kidney disease. Dose adjustment of Vincristine Sulphate may be needed. Please consult your doctor. [CAUTION] Vincristine Sulphate should be used with caution in patients with liver disease. Dose adjustment of Vincristine Sulphate may be needed. Please consult your doctor.

I want to know the symptoms of cancer as I am a smoker Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time. If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer I seem to have lung cancer , becoz all the symptoms are same as lung cancer. I test my blood, they suggests me that it is highly probable to lung cancer. Sir what can i do now. This is in preliminary stage Do you think that lung cancer is diagnosed from blood What is the purpose of Chemotherepy given at the time of radiotherapy in ca lung small cell carcinoma This is given to enhance the therapeutic effect of radiation therapy which is curative for small cell lung cancer. BREAST CANCER , PET REPORT SAYS INFECTION IN SKELETON. Metastatic breast cancer, send me previous treatment details I am PATIENT have pain in my breastes and feel very weight before one week of my menstrual perieds date Is it any symptoms of breast cancer ? Need your advice And also having back pain during menstrual dates please give your valubel advice No it's not a symptom of breast cancer. Sir my brother have skin cancer can you do something for save his life ?? Treatment of cancer depends on whether it is localized or metastatic cancer How we can find out parient is CA and which report we can do for know the patient is CA Thr is no single test for cancerWhich cancer ur looking for