Xemimax1gm/vial

Cefepime is an antibiotic that fights bacteria. It is used to treat severe bacterial infections of the skin, lungs, stomach, urinary tract, and blood. It works by killing the bacteria that cause these problems. However, it will not treat a viral infection. Cefepime is commonly used to treat critically ill patients admitted to the hospital. This medicine is given by drip or by direct injection into a vein, under the supervision of a healthcare professional. The dose depends on what type of infection you have, where it is in the body and how serious it is. You should have your injections at the same time each day to get the most benefit and you should keep on taking this medicine for as long as you are prescribed it, even if your symptoms quickly improve. If you stop taking it too early the infection may return or worsen. Some people may develop side effects like rash, itching, nausea, vomiting, headache, fever, diarrhea or local redness and swelling at the site of injection. These side effects are usually temporary and go away during treatment as your body adjusts to the medicine. Consult your doctor if these side effects bother you or do not go away. Before starting treatment with this medicine, you should tell your doctor if you have any liver or kidney problems or if you are allergic to any antibiotic. While using it, your doctor may advise blood tests to monitor your kidney function. This medicine is generally regarded as safe to use in pregnancy and breastfeeding if prescribed by your doctor. Cefepime is an antibiotic. It kills bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Bacterial infections

Cefepime is a 4th generation cephalosporin which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs).

Adult Dose: Adult: IV UTI 0.5-1 g 12 hrly for 7-10 days. Empirical therapy for febrile neutropenia 2 g 8 hrly for 7 days or until resolution of neutropenia. Moderate to severe pneumonia 1-2 g 12 hrly for 10 days. Complicated intra-abdominal infections 2 g 12 hrly for 7-10 days. Uncomplicated skin and skin structure infections 2 g 12 hrly for 10 days. Child Dose: Child: IV, IM 100 mg/kg/day q12h 150 mg/kg/day empiric therapy of fever with neutropenia q8h 2 mth - 16 yr: >40 kg: 50 mg/kg every 12 hr for 7-10 days for Uncomplicated and Complicated Urinary Tract Infections (including pyelonephritis), Uncomplicated Skin and Skin Structure Infections and Pneumonia.. May be given via direct inj over 5 minutes or infuse over 30 minutes. For empiric therapy for febrile neutropenic patients 2 mth - 16 yr: <40 kg: 50 mg/kg every 8 hr for 7 days or until neutropenia resolves. Renal Dose: Renal impairment: Haemodialysis: 1 g on the 1st day of treatment, followed by 0.5 g 24 hrly; dose should be given after haemodialysis on dialysis days and preferably at the same time each day. CAPD: Adult dose 48 hrly. CrCl (ml/min) <10 0.25-0.5 g 24 hrly. 11-29 0.5-1 g 24 hrly. 30-60 0.5-2 g 24 hrly.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Cefepime, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Rash • Itching • Nausea • Vomiting • Headache • Fever • Diarrhea

[CONSULT YOUR DOCTOR] It is not known whether Cefepime alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Your doctor has prescribed Cefepime to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection to come back and harder to treat. Discontinue Cefepime and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing. Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it doesn't stop or if you find blood in your stools. Avoid consuming alcohol while taking Cefepime as it may cause increased side effects.

Hypersensitivity to cefepime or other cephalosporins.

Increased potential for nephrotoxicity and ototoxicity of aminoglycosides. Increased risk of nephrotoxicity w/ potent diuretics (e.g. furosemide).

[SAFE] Consuming alcohol with Cefepime does not cause any harmful side effects.

[SAFE IF PRESCRIBED] Cefepime is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.

[SAFE IF PRESCRIBED] Cefepime is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Avoid prolonged use of Cefepime, since it may have possible effects such as rash and diarrhea.

[CAUTION] Cefepime should be used with caution in patients with kidney disease. Dose adjustment of Cefepime may be needed. Please consult your doctor. [SAFE IF PRESCRIBED] Cefepime is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Cefepime may not be needed in these patients. Please consult your doctor.

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