৳ 6,500/unit
Pack: ৳ 6,500
৳ 6,500/unit
Pack: ৳ 6,500
At a glance
Zoledronic Acid 5mg is used to treat or prevent weakening of the bones (osteoporosis) caused by menopause or use of steroids. It is also used to treat high levels of calcium in people who have cancer.
Indications
- Osteoporosis
- Hypercalcemia
- Paget's disease of bone
- Osteoporosis in postmenopausal women
- Increase bone mass in men with osteoporosis
- Corticosteroid-induced osteoporosis
- Prophylaxis of postmenopausal osteoporosis
Pharmacology
Zoledronic acid, an aminobiphosphonate, is a potent inhibitor of bone resorption. It inhibits osteoclastic activity and skeletal calcium release caused by tumours.
Dosage
Adult Dose (IV):
- Paget's disease of bone: 5 mg as a single infusion over 15 min
- Osteoporosis in postmenopausal women; Increase bone mass in men with osteoporosis; Corticosteroid-induced osteoporosis: 5 mg as a single infusion over at least 15 min, once yearly
- Prophylaxis of postmenopausal osteoporosis: 5 mg as a single infusion once every 2 years
Renal Impairment: CrCl >35 mL/min: no adjustment needed; CrCl <35 mL/min: contraindicated
Side effects
Common Side Effects:
- Headache
- Back pain
- Musculoskeletal pain
- Heartburn
- Diarrhea
Use in pregnancy
Use in Pregnancy: Unsafe; definite evidence of risk to the developing baby; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May affect ability to drive
- Drink plenty of fluids to prevent dehydration and kidney damage
- Can lower the level of calcium in the blood; take calcium and vitamin D supplements as suggested
- May develop fever or flu like symptoms; usually temporary
- May cause a rare condition called osteonecrosis of the jaw; have regular dental check-ups
- Do not take if pregnant or breastfeeding
Overdose effects
Symptoms: Hypocalcemia, hypophosphatemia, and hypomagnesemia.
Treatment: Correct by intravenous administration of calcium gluconate, potassium or sodium phosphate and magnesium sulfate.
Storage conditions
Store below 30°C prior to opening. Protect from moisture and light. Keep out of the reach and sight of children.