৳ 1/unit
Pack: ৳ 1
৳ 1/unit
Pack: ৳ 1
At a glance
Zidovudine belongs to a group of medicines called antiretrovirals. It is used to treat HIV (human immunodeficiency virus), the virus that can cause AIDS (acquired immunodeficiency syndrome). It helps to control HIV infection so your immune system can work better.
Indications
- HIV infection
Pharmacology
Zidovudine is a thymidine analogue. It is phosphorylated in the body to its active form zidovudine triphosphate which interferes in DNA synthesis of retroviruses by inhibiting DNA replication. Zidovudine inhibits the key enzyme reverse transcriptase.
Dosage
Adult Dose (Oral):
- HIV Infection: 300 mg PO every 12 hours OR 200 mg PO every 8 hours (600 mg/day)
Adult Dose (IV):
- 1 mg/kg/dose 5-6 times/day
Child Dose (Oral):
- 4 weeks-18 years: 240 mg/m² PO every 12 hours or 160 mg/m² PO every 8 hours
Renal Impairment: CrCl <15 mL/min: 100 mg PO or 1 mg/kg IV every 6-8 hours
Side effects
Common Side Effects:
- Fatigue
- Headache
- Decreased appetite
- Nausea
- Vomiting
- Muscle pain
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive
- Take with food, as this increases the absorption
- May cause dizziness or sleepiness; do not drive or do anything requiring concentration
- You may still develop infections or other illnesses associated with viral infection
- Regular blood tests are needed to monitor liver function, level of hepatitis B virus and blood cells
Overdose effects
Symptoms: Limited information.
Treatment: Supportive care.
Storage conditions
Store below 30°C in a dry place, away from light; keep out of reach of children.