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Omeprazole is a medicine that reduces the amount of acid produced in your stomach. It is used for treating acid-related diseases of the stomach and intestine such as heartburn, acid reflux, peptic ulcer disease, and some other stomach conditions associated with excessive acid production. Omeprazole is also used to prevent stomach ulcers and acidity that may be seen with the prolonged use of pain-killers. It belongs to a class of medicines known as proton pump inhibitors (PPIs). This medicine should be taken one hour before a meal, preferably in the morning. The dose will depend on your underlying condition and how you respond to the medicine. You should keep on taking it as prescribed even if your symptoms disappear quickly. You can increase the efficiency of the treatment by eating smaller meals more often and avoiding caffeinated drinks (like tea and coffee), and spicy or fatty foods. The most common side effects observed with this medicine include nausea, vomiting, headache, flatulence, diarrhea, and stomach pain. These symptoms are generally mild but if they bother you or do not go away, consult your doctor. Long-term use of this medicine may lead to an increased risk of side effects. For instance, using this medicine for more than 1 year may increase your risk for bone fractures, especially with higher doses. Talk to your doctor about ways to prevent bone loss (osteoporosis), like taking calcium and vitamin D supplements. Before taking this medicine, you need to tell your doctor if you have severe liver problems or allergic reactions to similar medicines in the past or suffer from bone loss (osteoporosis). Many other medicines may affect, or be affected by, this medicine so let your doctor know about all other medicines you are taking, to make sure it is safe. This is particularly important if you are taking medicines for HIV, fungal infections, tuberculosis, epilepsy (fits), or some types of blood thinners. Pregnant or breastfeeding women should also consult their doctor before taking it. Omeprazole is a proton pump inhibitor (PPI). It works by reducing the amount of acid in the stomach which helps in relief of acid related indigestion and heartburn.

• Gastroesophageal reflux disease (Acid reflux) • Peptic ulcer disease

Omeprazole is a substituted benzimidazole gastric antisecretory agent and is also known as PPI. It blocks the final step in gastric acid secretion by specific inhibition of H+/K+ ATPase enzyme system present on the secretory surface of the gastric parietal cell. Both basal and stimulated acid are inhibited.

Adult Dose: Oral Peptic ulcer Adult: 20 or 40 mg/day in severe cases for 4 wk (duodenal ulcer) or for 8 wk (gastric ulcer). Maintenance: 10-20 mg/day. All doses to be taken once in the morning. NSAID-associated ulceration Adult: 20 mg once in the morning. Gastro-oesophageal reflux disease Adult: 20 mg/day for 4 wk may continue for another 4-8 wk if necessary. Refractory oesophagitis: 40 mg/day. Maintenance: 20 mg/day (after healing of oesophagitis); 10 mg/day (acid reflux). All doses to be taken once in the morning. Zollinger-Ellison syndrome Adult: Initially, 60 mg once in the morning, adjust as required. Dose Range: 20-120 mg/day. Doses >80 mg are administered in 2 divided doses. Prophylaxis of acid aspiration during general anaesthesia Adult: 40 mg given in the evening and another 40 mg 2-6 hr pre-op. Acid-related dyspepsia Adult: 10 or 20 mg once in the morning for 2-4 wk. Erosive oesophagitis Adult: 20 mg/day for 4-8 wk. Maintenance of healing: 20 mg/day for up to 12 mth. All doses to be taken once in the morning. H.pylori infection Adult: As triple therapy: 20 mg bid or 40 mg once daily combined w/ amoxicillin 500 mg and metronidazole 400 mg both tid or combined w/ clarithromycin 250 mg and metronidazole 400 mg (or tinidazole 500 mg) both bid or combined w/ amoxicillin 1 g and clarithromycin 500 mg both bid. Duration: 7 or 10 days. As 2-wk dual therapy: 20 mg bid or 40 mg/day combined w/ either amoxicillin 750 mg to 1 g bid or w/ clarithromycin 500 mg tid. Intravenous Gastro-oesophageal reflux disease; Gastric and duodenal ulcers; NSAID-associated ulceration Adult: 40 mg once daily infused over 20-30 min or slow inj over 5 min until oral admin is possible. Zollinger-Ellison syndrome Adult: Initially, 60 mg/day, adjust according to response. Daily doses >60 mg/day should be given in 2 divided doses. Elderly: No dosage adjustment needed. Hepatic impairment: 10-20 mg/day. Child Dose: Oral GERD Indicated for treatment of GERD 1 year 5-10 kg: 5 mg PO qDay 10-20 kg: 10 mg PO qDay >20 kg: 20 mg PO qDay Erosive Esophagitis Indicated for treatment and to maintain healing of erosive esophagitis caused by acid-mediated GERD 10 kg: 10 mg qDay May treat for up to 6 weeks Aged 1-16 years 5 to 20 kg: 20 mg PO qDay May treat for 4-8 weeks Renal Dose: Renal impairment: No dosage adjustment needed.

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Omeprazole is to be taken empty stomach.

If you miss a dose of Omeprazole, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Diarrhea • Flatulence • Headache • Nausea • Stomach pain • Vomiting

[CONSULT YOUR DOCTOR] It is not known whether Omeprazole alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. It is a well-tolerated medicine and provides relief for a long time. Avoid eating late at night or before bedtime. Inform your doctor if you get watery diarrhea, fever or stomach pain that does not go away. Inform your doctor if you do not feel better after taking it for 14 days as you may be suffering from some other problem that needs attention. Long-term use of Omeprazole can cause weak bones and a deficiency of minerals such as magnesium. Take adequate dietary intake of calcium and magnesium or their supplements as prescribed by your doctor. Do not stop taking medication without talking to your doctor. Consult your doctor right away if you develop decreased urination, edema (swelling due to fluid retention), lower back pain, nausea, fatigue, and rash or fever. These could be signs of a kidney problem.

Known hypersensitivity to any of its component.

Increased risk of hypomagnesaemia w/ diuretics. May increase INR and prothrombin time w/ warfarin. Increased risk of digoxin-induced cardiotoxic effects. May increase plasma concentration benzodiazepines (e.g. diazepam), clarithromycin and methotrexate. Decreased absorption of itraconazole, ketoconazole, posaconazole, dasatinib, iron salts. May prolong elimination of diazepam, cilostazol, phenytoin and ciclosporin. May reduce the antiplatelet effect of clopidogrel. Potentially Fatal: May decrease plasma concentrations and pharmacological effects of rilpivirine, nelfinavir and atazanavir.

[CAUTION] Caution is advised when consuming alcohol with Omeprazole. Please consult your doctor.

[CONSULT YOUR DOCTOR] Omeprazole may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Omeprazole is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[SAFE IF PRESCRIBED] Omeprazole is safe to use in patients with kidney disease. No dose adjustment of Omeprazole is recommended. [CAUTION] Omeprazole should be used with caution in patients with severe liver disease. Dose adjustment of Omeprazole may be needed. Please consult your doctor. A lower dose may be advised in patients with liver disease and who have to take this medicine for a long time.

Heartburn Mental disorder Depression Frequent persistent heartburn Gastroesophageal reflux disease Irritable bowel syndrome Indigestion Back flow of acid from stomach Difficulty in swallowing Inflammation of esophagus Excess acid secretion by stomach Intestinal or stomach ulcers You need to be examined in clinic to reach a diagnosis and then appropriate medicine can be prescribed Having problem of acid reflux disease with throat infection and pain in right side of abdomen take avipattikar churan 1 spoon twice before meal, for throat infection do gargles with lyuke warm water and mixing tankan bhasma a littlein it,, My cough is not getting cured since 4-6 months. Tried some doctors, their medicines work for some time and the dry cough starts again. Though it happens occasionally, but i still cough It can be allergic cough or acid reflux disease. Can't give more opinion without seeing acid reflux, gastric, sugar stimulate acid reflux. CBC,ESR,LIPID PROFILE,URINE RE/CS, KFT, LFT, VIT D & B estimation,TAKE RABEKIND DSR once a day empty stomach FOR 3 week only during late mid night hours i feel acid reflux in throat with slight irritation.no other symptoms like heartburn and indigestion.i drink apple cider vinegar before bed but that's not helping.i have dinner at 7pm and sleep at 10 30pm. vegetarian i wont drink carbonated drinks and eat fatty acid foods can you prescribe me some medicines Take omez d once daily in evening at 6 pm for 2 week Suffering from acid reflux disease due to which pain in throat and right side of lower abdomen Dear sir for the time being you can take Robinia 30, 04 drops in half cup water and Nixocid tab 2 tab thrice daily for a month, but as this case needs supervision, discussion and examination you need to visit a homeopath so that he can discuss your case in detail, get some investigations, do examination and guide you accordingly, Moderate Throat Pain in left side Moderate Ear pain. Acid reflux too often it may be due to acidity also you may have got some ulcer or infection in that region visit ent specialist near you for proper examination irritation in throat, hawking , better from Lachesis,better from Acidity capsule Seems to be u are having acid reflux or nasal discharge. Consult a ENT specialist for proper clinical examination