osudhkosh

Generic

Aminocaproic Acid

5 brands available in the market

At a glance

Aminocaproic acid is an antifibrinolytic drug used to treat excessive postoperative bleeding and reverse thrombolytic agent overdose.

Description

Hemostatic agent that inhibits fibrinolysis by blocking plasminogen activators, reducing blood loss in surgeries like CABG.

Indications

Used to treat excessive postoperative bleeding, reduce blood loss in cardiac surgery, and manage thrombolytic agent overdose.

Therapeutic class

Anti-fibrinolytic drugs, Haemostatic drugs

Pharmacological class

Fibrinolysis Inhibitor

Pharmacology

Inhibits plasminogen activators and exhibits antiplasmin activity to prevent blood clot breakdown.

Mechanism of action

Blocks the conversion of plasminogen to plasmin, stabilizing fibrin clots.

Dosage

Average dose 8-16 g/day divided every 4-6 hours; up to 20-25 g in 24 hours for severe cases. IV infusion guidelines apply.

Administration

Can be given orally or intravenously with suitable dilution.

Missed dose

Take or administer as scheduled.

Side effects

Mild muscle pain, weakness, headache, nausea, vomiting, diarrhea, nasal congestion, vision changes, injection site reactions.

Precautions & warnings

Safety and efficacy have not been established in patients younger than 18 years.

Contraindications

Active intravascular clotting process or DIC without concomitant heparin.

Drug interactions

Use with caution alongside other hemostatic or thrombolytic agents.

Food interactions

Can be taken with or without food; take with food to prevent GI upset.

Use in pregnancy

Pregnancy Category C. Use only if clearly needed.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Use in lactation

Consult physician during lactation.

Pediatric use

Not established in pediatric patients under 18.

Geriatric use

Use with caution under medical supervision.

Renal / hepatic impairment

Cleared renally; use with monitoring in renal or hepatic impairment.

Overdose effects

Supportive management.

Storage conditions

Store in a cool, dry place, protected from light. Suspension below 30°C. Keep out of reach of children.

Chemical structure

6-aminohexanoic acid

Common questions

What is Aminocaproic acid used for?
It is used to treat excessive postoperative bleeding, reduce blood loss in cardiac surgery, and manage thrombolytic agent overdose.
What is the dosage/administration?
It can be given orally or intravenously, with dosage adjusted according to the severity of the hemorrhagic event under medical supervision.
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.