Antazoline + Tetryzoline

Antazoline + Tetryzoline is an ophthalmic solution combining an H1-antihistamine (Antazoline) and an alpha-adrenergic sympathomimetic vasoconstrictor (Tetryzoline) for the temporary relief of allergic conjunctivitis symptoms including conjunctival hyperaemia, chemosis, and itching.

Antazoline blocks H1 histamine receptors to relieve itching, while Tetryzoline acts as a vasoconstrictor to reduce redness and edema. This combination provides effective symptomatic relief for allergic eye diseases.

Adults and adolescents: 1 drop 2-3 times daily up to 14 days. Not for use in children below 2 years of age.

• Allergic conjunctivitis
• Conjunctival hyperaemia (redness)
• Chemosis (swelling)
• Ocular itching

Antazoline is an antihistamine of the ethylenediamine class, which are selective H1-antagonists. Effects mediated by H1 receptors include contraction of smooth muscle and dilation and increased permeability of capillaries. Antihistamines are highly effective in relieving itching but are not very active in relieving redness.

Tetryzoline is a sympathomimetic with alpha-adrenergic activity. Its vasoconstrictive effect reduces redness and edema in allergic conjunctivitis.

The combination of an antihistamine and a vasoconstrictor is well established in the symptomatic relief of allergic eye disease.

Antazoline blocks H1 histamine receptors, preventing histamine-mediated effects including itching. Tetryzoline stimulates alpha-adrenergic receptors, causing vasoconstriction of ocular blood vessels, which reduces redness and edema. Together, these mechanisms provide rapid relief from allergic conjunctivitis symptoms.

Adults & Adolescents: 1 drop 2-3 times daily up to 14 days.

Children (above 2 years): No specific studies available. For possible systemic effects, dosage should not exceed 1-2 drops per day.

Children (below 2 years): Not to be used in children below 2 years of age.

Important: Should not be used for longer than 14 days as this may cause rebound hyperemia and toxic follicular conjunctivitis.

For ophthalmic use only. Close the bottle tightly after use. Do not allow the dropper tip to touch the eye or any other surface during use.

If you miss a dose, apply as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not double the dose.

Mild and transient burning or stinging upon instillation is the most common side effect.

Precautions:

• Use with caution in elderly patients with severe cardiovascular disease (including arrhythmia), poorly controlled hypertension or diabetes
• Do not use for longer than 14 days (risk of rebound hyperemia and toxic follicular conjunctivitis)
• Consult doctor before use if wearing contact lenses
• Keep dropper tip clean

• Hypersensitivity to Antazoline, Tetryzoline, or any excipient
• Concomitant use with Monoamine Oxidase Inhibitors (MAOIs)
• Children below 2 years of age

• MAOIs: Sympathomimetic agents may cause hypertensive crisis if used during MAOI treatment - concomitant use is contraindicated
• Sedating antihistamines: Can enhance sedating effects of CNS depressants (alcohol, hypnotics, opioid analgesics, anxiolytic sedatives, anti-psychotics)
• Anti-muscarinic drugs: Additive anti-muscarinic action with atropine and antidepressants

Can be taken with or without food.

No clinical data on exposed pregnancies are available. Use only if potential benefits outweigh the risks to the fetus. Consult your doctor before use during pregnancy.

It is not known whether the active substances pass into breast milk. Caution should be exercised when using the product during breast-feeding.

Not to be used in children below 2 years of age. For children above 2 years, dosage should not exceed 1-2 drops per day.

Use with caution in elderly patients with severe cardiovascular disease, arrhythmia, poorly controlled hypertension, or diabetes.

No specific dose adjustments required for patients with renal or hepatic impairment.

In case of topical overdose, flush eyes with warm tap water.

Use within 30 days after first opening. Store at 15-25°C, protected from light. Close bottle tightly immediately after use. Keep out of reach of children.

Antazoline 0.05% + Tetryzoline 0.04%