Generic
Atracurium Besilate
1 brands available in the market
At a glance
Atracurium Besilate is a non-depolarizing neuromuscular blocking agent used to facilitate endotracheal intubation, mechanical ventilation, and muscle relaxation during surgery.
Description
An injectable skeletal muscle relaxant that competitively blocks acetylcholine receptors at the neuromuscular junction, providing controlled muscle paralysis.
Indications
Indicated for endotracheal intubation, facilitating mechanical ventilation in intensive care, and as a muscle relaxant in general anaesthesia.
Therapeutic class
Non depolarizing muscle relaxants
Pharmacological class
Non-depolarizing Neuromuscular Blocker
Pharmacology
Antagonizes acetylcholine at the motor end-plate cholinergic receptors. Neuromuscular blockade can be reversed by acetylcholinesterase inhibitors like neostigmine.
Mechanism of action
Competitively binds to nicotinic acetylcholine receptors on the motor end-plate, preventing depolarization.
Dosage
Adult and Child (>1 month): Initially 300-600 mcg/kg as IV bolus, with maintenance doses of 100-200 mcg/kg IV every 15-25 min or 5-10 mcg/kg/min by infusion.
Administration
Intravenous administration under clinical supervision.
Missed dose
Administered strictly in clinical settings.
Side effects
Flush, erythema, pruritus, urticaria, wheezing, bronchospasm, bradycardia, injection site reactions. Potentially fatal: Anaphylaxis.
Precautions & warnings
Use with caution in patients with cardiovascular disease, asthma, burn injuries, myasthenia gravis, or electrolyte imbalances.
Contraindications
Known hypersensitivity to atracurium, cisatracurium, or benzenesulfonic acid.
Drug interactions
Enhanced effect with inhalation anesthetics, aminoglycosides, lithium, magnesium salts, and antiarrhythmics.
Food interactions
Not applicable.
Use in pregnancy
Pregnancy Category C. Use only if potential benefit justifies potential risk.
Pregnancy Category: Category C — always consult a doctor before taking during pregnancy.
Use in lactation
Use with caution during breastfeeding under medical guidance.
Pediatric use
Approved for children over 1 month of age.
Geriatric use
Use with caution.
Renal / hepatic impairment
No specific dose adjustment required.
Overdose effects
Causes histamine release and hypotension; requires artificial ventilation and cardiovascular support.
Storage conditions
Store between 2-8°C. Do not freeze. Protect from light.
Chemical structure
Benzylisoquinoline derivative