Generic
Calcium Phosphate + Vitamin D3
1 brands available in the market
At a glance
Calcium Phosphate + Vitamin D3 is a combination tablet used in the treatment of osteoporosis, osteomalacia, tetany, hypoparathyroidism, osteogenesis, rickets, calcium and vitamin D3 deficiency, pregnancy and lactation, and kidney disease and pancreatitis.
Description
Calcium Phosphate + Vitamin D3 is a combination tablet used to improve bone health and supplement calcium and vitamin D3 deficiency. Each film-coated tablet contains Calcium Phosphate BP 715 mg (equivalent to Elemental Calcium 250 mg) and Cholecalciferol (Vitamin D3) USP 250 IU.
Calcium is absorbed in the intestine, which then passes through the intestine to blood and is deposited into bone. Active transport through cells is dependent on Vitamin D3. Vitamin D3 keeps bones healthy by increasing the absorption of calcium in the intestines. Without vitamin D3, the body can absorb only 10% to 15% of calcium from the diet.
Indications
- Osteoporosis
- Osteomalacia
- Tetany
- Hypoparathyroidism
- Osteogenesis
- Inadequate intake of calcium in childhood diet
- Rickets
- Pregnancy and lactation
- Poor absorption during old age
- Kidney disease and pancreatitis
- Prevention and treatment of calcium and vitamin D3 deficiency
Therapeutic class
Specific mineral & vitamin combined preparations
Pharmacological class
Calcium + Vitamin D3 Combination
Pharmacology
Calcium is absorbed in the intestine, which then passes into the blood and is deposited into bone. Active transport through cells is dependent on vitamin D3. Vitamin D3 keeps bones healthy by increasing the absorption of calcium in the intestines. Without vitamin D3, the body can absorb only 10% to 15% of calcium from the diet.
Mechanism of action
Calcium is absorbed in the intestine and deposited into bone. Vitamin D3 increases calcium absorption in the intestine and regulates bone mineralization.
Dosage
Adults: 2 tablets once or twice daily (i.e., 2-4 tablets per day) with plenty of water or food, or as directed by the physician.
Note: Dosage is determined by the physician based on the patient's clinical condition.
Administration
Take with plenty of water or food. Swallow tablets whole; do not chew or crush. Follow the dose and duration as advised by your physician.
Missed dose
If you miss a dose, take it as soon as you remember. Skip the missed dose if it is almost time for your next dose. Do not double the dose.
Side effects
- Rare side effects: Flatulence, diarrhea, constipation, allergic reactions.
Prolonged use (rare): Hypercalcemia has been reported.
Precautions & warnings
- In mild hypercalciuria, dose reduction is sufficient to return to normal serum calcium concentration.
- Patients with kidney stone or history of kidney stones should be advised to increase fluid intake.
- Avoid use in increased parathyroid activity, hypercalcemia, constipation, kidney stone, and extreme loss of body water.
Contraindications
- Increased activity of parathyroid gland
- Hypercalcemia
- Constipation
- Kidney stone
- Extreme loss of body water
Drug interactions
- Major interaction: IV Ceftriaxone + Calcium can cause life-threatening damage to the lungs and kidneys. Calcium should not be given intravenously within 48 hours of IV ceftriaxone.
- Minor interaction: Calcium reduces absorption of tetracycline and fluoride preparations (allow at least 3 hours gap). Thiazide diuretics reduce renal excretion of calcium. Phenytoin, barbiturates, and glucocorticoids may induce vitamin D3 metabolism. Certain foods (spinach, cereals, milk, and derivatives) may reduce intestinal calcium uptake.
Food interactions
Spinach, cereals, milk, and dairy products may reduce calcium absorption; avoid taking calcium supplements with these foods.
Use in pregnancy
Should be given to pregnant and lactating mothers as per the recommendation of the physician. Toxicity of calcium and vitamin D3 was tested on pregnant and nursing females which resulted excellent.
Use in lactation
Should be given to pregnant and lactating mothers as per the recommendation of the physician.
Pediatric use
Use in children under medical supervision (for inadequate calcium intake in childhood diet and rickets).
Geriatric use
Can be used as a supplement for poor absorption during old age; consult your doctor.
Renal / hepatic impairment
Hepatic impairment: Caution required in liver disease; consult your doctor.
Overdose effects
Overdose may cause hypercalcemia, hypercalciuria. Symptoms: nausea, vomiting, constipation, confusion. Consult your doctor immediately if overdose is suspected.
Storage conditions
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Chemical structure
Calcium Phosphate 715 mg (equiv. Elemental Calcium 250 mg) + Cholecalciferol (Vitamin D3) 250 IU