Cefoperazone

Cefoperazone is an antibiotic medicine used to treat bacterial infections in your body. It is effective in infections of the lungs (eg. pneumonia), ear, urinary tract, skin and soft tissues, bones and joints, blood, and heart. It is also used to prevent infections during surgery. Cefoperazone fights and stops the growth of many types of bacteria. This helps to improve your symptoms and cure the underlying infection. It is given as a drip (intravenous infusion) or as an injection directly into a vein or a muscle under the supervision of a healthcare professional. Your doctor will decide the correct dose for you. You should use this medicine regularly at evenly spaced intervals as per the schedule prescribed by your doctor. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping the medicine too early may lead to the infection returning or worsening. The most common side effects of this medicine include diarrhea and changes in liver function tests and blood counts. Some people may develop temporary redness or pain at the site of injection. These side effects are usually mild but let your doctor know if they bother you or last more than a few days. Avoid consuming alcohol while taking this medicine as it may cause increased side effects. Before using it, you should tell your doctor if you are allergic to any antibiotics, and if you have any liver or kidney problems. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by this medicine. Pregnant and breastfeeding mothers should consult their doctor before using it.

Cefoperazone is an antibiotic. It kills the bacteria by preventing them from forming the bacterial protective covering (cell wall) which is needed for them to survive.

• Respiratory Tract Infections
• Peritonitis & Other Intra-abdominal Infections
• Bacterial Septicemia
• Skin and Skin Structure Infections
• Pelvic Inflammatory Disease
• Endometritis & Other Infections of the Female Genital Tract
• Urinary Tract Infections
• Enterococcal Infections

Cefoperazone is a bactericidal Cephalosporin antibiotic which is resistant to most beta-lactamases and active against a wide range of aerobic & anaerobic, Gram positive & Gram negative bacteria. The bactericidal action of Cefoperazone results from the inhibition of bacterial cell wall synthesis. Cefoperazone has a high degree of stability in the presence of beta-lactamases produced by most Gram negative pathogens. Cefoperazone is usually active against organisms which are resistant to other beta-lactam antibiotics because of beta-lactamase production.

Cefoperazone binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.

Adult Dose (Parenteral):

Hepatic Dose: Hepatic impairment or biliary obstruction: Maximum 4 g/day.

Renal Dose: Renal impairment: 1-2 g/day. With hepatic impairment: 1-2 g/day.

Your doctor or nurse will give you this medicine. Kindly do not self administer.

If you miss a dose of Cefoperazone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common Side Effects:

• Increased liver enzymes
• Allergic reaction
• Anemia (low red blood cell count)
• Diarrhea
• Redness and pain at injection site

• [SAFE] Cefoperazone does not usually affect your ability to drive.
• Your doctor has prescribed Cefoperazone to cure your infection and improve your symptoms. Do not skip any doses and finish the full course of treatment even if you feel better. Stopping it early may make the infection harder to treat.
• Discontinue Cefoperazone and inform your doctor immediately if you get a rash, itchy skin, swelling of face and mouth, or have difficulty in breathing.
• Diarrhea may occur as a side effect but should stop when your course is complete. Inform your doctor if it does not stop or if you find blood in your stools.
• Avoid consuming alcohol while taking Cefoperazone as it may cause increased side effects.
• Cefoperazone is extensively excreted in bile. The serum half-life of Cefoperazone is increased 2-4 fold in patients with hepatic disease and/or biliary obstruction.

• Hypersensitivity to cephalosporin-class antibiotics.

Disulfiram-like reaction with alcohol. Potentiates anticoagulants. Enhances nephrotoxicity by aminoglycosides and furosemide.

[UNSAFE] Consuming alcohol while taking Cefoperazone may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).

[SAFE IF PRESCRIBED] Cefoperazone is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies. Pregnancy Category B. This drug should be used during pregnancy only if clearly needed.

[SAFE IF PRESCRIBED] Cefoperazone is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby. Only low concentrations of Cefoperazone is excreted in human milk. Avoid prolonged use of Cefoperazone, since it may have possible effects such as rash and diarrhea.

Safety and effectiveness in children have not been established.

Reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range.

[SAFE IF PRESCRIBED] Cefoperazone is safe to use in patients with kidney disease. No dose adjustment of Cefoperazone is recommended.

[CONSULT YOUR DOCTOR] There is limited information available on the use of Cefoperazone in patients with liver disease. Please consult your doctor. In patients with hepatic disease and/or biliary obstruction, total daily dosage above 4 g should not be necessary.

Information on Cefoperazone overdosage is not available.

Cefoperazone is to be stored in a dry place, below 25°C and protected from light prior to reconstitution. The reconstituted solution may be stored for 24 hours if kept in room temperature (below 25°C).

Cefoperazone Sodium