Generic
Clotrimazole 1% Eye prep
3 brands available in the market
At a glance
Clotrimazole 1% Eye prep is an antifungal medication used for the treatment of fungal keratitis and fungal eye infections.
Description
Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur. The primary action of clotrimazole is against dividing and growing organisms. Clotrimazole inhibits ergosterol synthesis, resulting in abnormal cellular permeability. This inhibits fungal growth. Clotrimazole Eye prep is used for the treatment of fungal eye infections and fungal keratitis.
Indications
- Fungal keratitis
- Fungal eye infections
Therapeutic class
Antifungals (Ophthalmic)
Pharmacological class
Topical Antifungal (Ophthalmic Preparation)
Pharmacology
Clotrimazole kills fungi and yeasts by interfering with their cell membranes. It works by stopping the production of ergosterol, which is an essential component of fungal cell membranes resulting in increased membrane permeability and leakage of essential constituents of the fungal cells.
Mechanism of action
Clotrimazole is a broad-spectrum antifungal which binds to phospholipids in the cell membrane altering cell wall permeability causing a loss in essential intracellular elements.
Dosage
Adult Dose (Ophthalmic): Apply thinly and evenly to the conjunctival sac every 4 hours daily.
Administration
This medicine is for ophthalmic use only. Apply a small amount to the conjunctival sac every 4 hours. Shake well before use. Do not touch the dropper tip to the eye or any other surface.
Missed dose
If you miss a dose of Clotrimazole 1% Eye prep, use it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.
Side effects
This drug is generally well tolerated.
Precautions & warnings
- For ophthalmic use only.
- If local intolerance develops, consider withdrawal of the medicine and institution of appropriate therapy.
- Caution during pregnancy and lactation.
- Not recommended in children under 3 years.
Contraindications
- Hypersensitivity.
Drug interactions
Antagonism with polyene antibiotics.
Food interactions
No food interactions have been found or established.
Use in pregnancy
Limited information is available regarding the use of Clotrimazole 1% Eye prep during pregnancy. Consult your doctor before use.
Use in lactation
Limited information is available regarding the use of Clotrimazole 1% Eye prep during breastfeeding. Consult your doctor before use.
Pediatric use
Not recommended in children under 3 years.
Geriatric use
Limited information is available regarding dose adjustment for elderly patients.
Renal / hepatic impairment
For topical/ophthalmic use, no dose adjustment is required in renal or hepatic impairment.
Overdose effects
Information on overdosage is not available. Consult a physician if overdose is suspected.
Storage conditions
Store in a cool and dry place, away from light and out of reach of children.
Chemical structure
Clotrimazole 1%