Generic
Coenzyme Q10 [Ubidecarenone]
45 brands available in the market
At a glance
Coenzyme Q10 [Ubidecarenone] is a vitamin-like substance with antioxidant properties used for nutritional deficiencies, heart disease, neurological disorders, infertility, and various other conditions.
Description
Coenzyme Q10 [Ubidecarenone] is a medicine used in the treatment of nutritional deficiencies. It has good antioxidant properties and a number of other health benefits. Coenzyme Q10 [Ubidecarenone] should be taken along with food. Take it regularly and at a fixed time each day to get maximum benefit from it. Inform your doctor before taking the medicine if you have any other medical conditions or are taking any other medications.
Coenzyme Q10 [Ubidecarenone] is a vitamin-like substance that provides essential nutrients. It is presented in every cell of the body and acts as a vital intermediate of the electron transport system in the mitochondrial membrane for cellular respiration and ATP production.
Indications
- Nutritional deficiencies
- Female and male infertility
- Neurological disorders (myopathy, ataxia, migraine, Parkinson's, Alzheimer's)
- Cardiovascular disease (CHF, hypertension, angina, cardiomyopathy)
- Diabetes
- Cancer
- Asthma
- Thyroid disorder
- Periodontal gum disease
Therapeutic class
Herbal and Nutraceuticals, Supplements & adjuvant therapy
Pharmacological class
Antioxidant (Vitamin-like Substance)
Pharmacology
The USP refers to Coenzyme Q10 as Ubidecarenone which is a fat-soluble vitamin like substance. It is presented in every cell of the body and acts as a vital intermediate of the electron transport system in the mitochondrial membrane for cellular respiration and ATP production. The highest requirement of Ubidecarenone is found in the cells and tissues that are of metabolically active such as- heart, immune system, skeleton muscle, gingiva and most susceptible to Ubidecarenone deficiency. The Production of Ubidecarenone slows down with advancing age and thus contribute in manifestation of aging.
Mechanism of action
Involved in electron transport chain. Antioxidant, membrane stabilizer.
Dosage
Adult Dose (Oral): 1 capsule daily; may be increased up to 3 capsules daily if needed. Daily doses range from 5 to 300 mg; effectiveness is thought to be obtained with 50-200 mg daily.
Doses for Specific Conditions:
- Coenzyme Q10 deficiency: 150 mg/day
- Mitochondrial disorders: 150-160 mg or 2 mg/kg/day
- Heart failure: 100 mg/day in 2-3 divided doses
- Hypertension: 120-200 mg/day in 2 divided doses
- Migraine prevention: 100 mg three times daily
- Parkinson's disease: 300-2400 mg/day in 3-4 divided doses
- Male infertility: 200-300 mg/day
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Coenzyme Q10 [Ubidecarenone] is to be taken with food.
Missed dose
If you miss a dose of Coenzyme Q10 [Ubidecarenone], take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common Side Effects:
- Nausea
- Loss of appetite
- Diarrhea
- Heartburn
- Stomach upset
- Vomiting
- Allergic skin rashes
Precautions & warnings
- [UNSAFE] Coenzyme Q10 [Ubidecarenone] may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur.
- May lower blood sugar levels; caution in patients with diabetes or hypoglycemia.
- May decrease blood pressure; caution in patients with low blood pressure or taking blood pressure medications.
- Contraindicated in patients scheduled for surgery in the next two weeks.
Contraindications
- Hypersensitivity
- Patients scheduled for surgery in the next two weeks
Drug interactions
Statins: Statins reduce endogenous synthesis of Ubidecarenone; supplementation may increase levels without affecting statin efficacy.
Warfarin: May reduce the effectiveness of warfarin.
Beta-blockers: Beta-blockers (particularly propranolol) may inhibit some Ubidecarenone dependent enzymes.
Antidiabetic medications: May improve glycemic control; dose adjustment may be needed.
Doxorubicin: May help ameliorate the cardiotoxicity of doxorubicin.
Food interactions
[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Coenzyme Q10 [Ubidecarenone]. Please consult your doctor.
Use in pregnancy
[SAFE IF PRESCRIBED] Coenzyme Q10 [Ubidecarenone] is generally considered safe to use during pregnancy. Animal studies have shown low or no adverse effects to the developing baby; however, there are limited human studies.
Use in lactation
[CAUTION] Coenzyme Q10 [Ubidecarenone] should be used with caution during breastfeeding. Breastfeeding should be held until the treatment of the mother is completed and the drug is eliminated from her body.
Pediatric use
Limited information is available regarding use in children.
Geriatric use
Limited information is available regarding dose adjustment for elderly patients.
Renal / hepatic impairment
[CONSULT YOUR DOCTOR] There is limited information available on the use of Coenzyme Q10 [Ubidecarenone] in patients with kidney disease. Please consult your doctor.
[CONSULT YOUR DOCTOR] There is limited information available on the use of Coenzyme Q10 [Ubidecarenone] in patients with liver disease. Please consult your doctor.
Overdose effects
Information on Coenzyme Q10 [Ubidecarenone] overdosage is not available. Consult a physician if overdose is suspected.
Storage conditions
Keep in a dry place away from light and heat. Keep out of reach of children.
Chemical structure
Ubidecarenone (Coenzyme Q10)