Dasatinib

Dasatinib is used in the treatment of blood cancer (chronic myeloid leukaemia). It is used in patients whose disease could not be treated with other medications for leukaemia or who cannot take these medications because of side effects. Dasatinib can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, vomiting, abdominal pain and rash are some common side effects of this medicine. In some cases, it may cause increased heartbeat and low or high blood pressure, if it happens consult with your doctor. Your doctor might check your blood pressure regularly. It is advised to avoid antacid intake within 2 hours of taking this medicine. This medicine may reduce the number of blood cells in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. You must avoid driving if you experience dizziness or blurred vision during treatment. Dasatinib is an anti-cancer medication. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.

• Blood cancer (Chronic myeloid leukaemia)

Dasatinib is an inhibitor of multiple tyrosine kinases. It is used for the treatment of all phases of chronic myeloid leukaemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukaemia (ALL) in adults who have resistance or intolerance to previous therapy, including imatinib.

Adult Dose: Oral Chronic myeloid leukaemia Adult: Chronic phase CML: Initially, 100 mg once daily, may increase up to 140 mg once daily. Accelerated, myeloid or lymphoid blast phase CML or Philadelphia chromosome-positive ALL: Initially, 140 mg once daily, may increase up to 180 mg once daily. Hepatic impairment: No dosage adjustment needed.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Dasatinib may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Dasatinib, skip it and continue with your normal schedule. Do not double the dose.

Common: • Abdominal pain • Anemia (low number of red blood cells) • Breathing problems • Fatigue • Fever • Headache • Infection • Low blood platelets • Musculoskeletal (bone, muscle or joint) pain • Nausea • Rash • Vomiting

[UNSAFE] Dasatinib may cause side effects which could affect your ability to drive. Take special care when driving in case you experience side effects such as dizziness and blurred vision with Dasatinib. Take it with or without food, preferably at the same time each day. Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it. Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting. It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools. Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Concomitant use w/ CYP3A4 inhibitors (e.g. atazanavir, clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin, voriconazole or grapefruit juice); CYP3A4 inducers (e.g. carbamazepine, dexamethasone, phenytoin, phenobarbital, rifampicin or St John's wort); antacid. Pregnancy.

Concomitant use w/ drugs that have narrow therapeutic index (e.g. alfentanil, cisapride, ciclosporin, fentanyl, pimozide, quinidine, simvastatin, sirolimus, tacrolimus, ergot alkaloids) as it may increase the serum levels of these drugs. Increased risk of bleeding and thrombocytopenia w/ antiplatelet drugs, anticoagulants, and NSAIDs. Potentially Fatal: May reduce plasma levels w/ antacids, administer antacid 2 hr apart from the admin of dasatinib. May increase plasma levels w/ CYP3A4 inhibitors (e.g. atazanavir, clarithromycin, erythromycin, indinavir, itraconazole, ketoconazole, nefazodone, nelfinavir, ritonavir, saquinavir, telithromycin or voriconazole). May reduce plasma levels w/ CYP3A4 inducers (e.g. carbamazepine, dexamethasone, phenytoin, phenobarbital or rifampicin).

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Dasatinib. Please consult your doctor.

[CONSULT YOUR DOCTOR] Dasatinib is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Dasatinib is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Dasatinib is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Dasatinib may not be needed in these patients. Please consult your doctor. [SAFE IF PRESCRIBED] Dasatinib is safe to use in patients with liver disease. No dose adjustment of Dasatinib is recommended.

She is suffering from chronic myeloid leukemia Hi Kindly consult to Ayurvedic doctor at your local city area , face to face consult is needed. Mh mother have blood cancer .recently she got her first induction chemotherapy.in CBC test Immature myeloid cells 18 percent what are indicate.is it serious .is it shown presence of cancer in blood old tell me Dear Mam Greetings from 1mg, The reports shows low hemoglobin and platelet count which can be due to chemotherapy. My frnds are saying that this reports are signs of leukemia Please please help and suggest your opinions and if no what medicine can be taken It's curable cancer now a days, so don't worry. Get evaluated and find out which Leukaemia you have. Then we will decide for treatment. Is there anything related to blood cancer sir/madam?? For that we need to do bone marrow aspiration, flow cytometry.CBC suggestive of chronic Leukaemia soEven if it is Leukaemia, it will need not to be treated as it is asymptomatic in majority of times. I want to know the symptoms of cancer as I am a smoker Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time. Can blood cancer patients 1st stage do sex with normal girl Sir a blood cancer patients do sex with normal girl can any problem or cause doing with girl or side effect give suggestions Thanks Wait till blood cancer gets cured. Blood Cancer. Is there any medicine to cure blood cancer. Case has to be seen in person What is t-cell all ??? And treatment This is my mother first born mero report Now the blast is less then 5% after 1 month treatment This is blood cancerShe is in remission