Desoximetasone

Desoximetasone is a topical corticosteroid that induces phospholipase A2 inhibitory proteins (lipocortins) and sequentially inhibits the release of arachidonic acid hence depresses the formation, release, and activity of endogenous chemical mediators such as kinins, histamine, liposomal enzymes, and prostaglandins. It provides relief from swelling, redness, and itching in the affected area.

• Corticosteroid-responsive dermatoses
• Eczema
• Atopic dermatitis

The precise mechanism of the antiinflammatory activity of topical steroids is uncertain. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.

Desoximetasone induces phospholipase A2 inhibitory proteins, reducing arachidonic acid release and decreasing production of inflammatory mediators such as prostaglandins and leukotrienes, thereby reducing skin inflammation and itching.

Adults & Children: Apply a thin film of 0.05-0.25% cream/gel/lotion/ointment to affected areas twice daily. Rub in gently.

For external use only. Clean and dry the affected area and apply a thin layer of cream. Avoid contact with eyes. Wash hands after application.

If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.

Common: Burning, itching, irritation, dryness at application site.
Rare (with occlusive dressings): Folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, skin maceration, skin atrophy, striae, miliaria.

For external use only; avoid eye contact; do not use occlusive dressings (unless directed by doctor); discontinue if infection develops; consult doctor if no improvement within 2 weeks; do not stop abruptly.

Hypersensitivity.

Aldesleukin: May diminish antineoplastic effect.
Ceritinib: May potentiate hyperglycaemic effect.
Corticorelin, hyaluronidase: May diminish therapeutic effect.
Deferasirox: May enhance adverse/toxic effects.

Can be used with or without food.

Pregnancy Category C. Desoximetasone may be unsafe during pregnancy. Animal studies have shown harmful effects on the developing baby. Use only if clearly needed.

Desoximetasone is probably safe during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

Pediatric patients may use the same dosage as adults.

No specific dosage adjustment is necessary for elderly patients.

No special precautions are necessary for patients with kidney or liver problems.

Topically applied Desoximetasone can be absorbed in sufficient amounts to produce systemic effects.

Do not store above 30°C. Keep away from light and out of reach of children.

Desoximetasone