Generic
Dexamethasone + Gatifloxacin
7 brands available in the market
At a glance
Dexamethasone + Gatifloxacin is an eye drop used for the treatment of bacterial eye infections. It stops the growth of bacteria and helps in relieving redness, itching and swelling.
Description
Gatifloxacin's antibacterial action results from inhibition of DNA gyrase and topoisomerase IV. Dexamethasone inhibits phospholipase A2, the first step in prostaglandin synthesis, and inhibits chemotactic infiltration of neutrophils into the site of inflammation.
Indications
- Steroid-responsive inflammatory ocular conditions with bacterial involvement
- Blepharitis, scleritis, episcleritis, iritis, cyclitis, iridocyclitis
- Choroiditis, optic neuritis, chronic anterior uveitis
- Disciform and interstitial keratitis, allergic corneal marginal ulcers
- Corneal injury from chemical, radiation or thermal burns
Therapeutic class
Ophthalmic steroid - antibiotic combined preparations
Pharmacological class
Fluoroquinolone Antibiotic + Corticosteroid
Pharmacology
Gatifloxacin's antibacterial action results from inhibition of DNA gyrase and topoisomerase IV. Dexamethasone inhibits phospholipase A2, the first step in prostaglandin synthesis, and inhibits chemotactic infiltration of neutrophils into the site of inflammation.
Mechanism of action
Gatifloxacin kills bacteria by inhibiting bacterial DNA gyrase and topoisomerase IV; Dexamethasone reduces inflammation by inhibiting phospholipase A2.
Dosage
Adult: Instill 1-2 drops into the conjunctival sac 3 to 4 times daily.
Administration
For ophthalmic use only. Wash hands, hold the dropper close to the eye without touching it, place the medicine inside the lower eyelid. Wipe off extra liquid.
Missed dose
If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.
Side effects
Gatifloxacin-related: Chemosis, redness, dry eye, itching, eyelid swelling, reduced visual acuity.
Dexamethasone-related: Elevation of intraocular pressure, delayed wound healing, posterior subcapsular cataract formation.
Precautions & warnings
If used for 10 days or more, intraocular pressure should be monitored routinely. Prolonged steroid use may result in glaucoma or other ocular damage. May exacerbate viral infections. Use cautiously in patients with history of herpes simplex.
Contraindications
Fungal disease of ocular structures; viral conjunctivitis; hypersensitivity to any component.
Drug interactions
Antacids (aluminum, calcium, magnesium), digoxin, probenecid, vitamins (zinc, calcium, magnesium, iron): May interact with gatifloxacin.
Food interactions
Can be used with or without food.
Use in pregnancy
There are no adequate and well-controlled studies in pregnant women; should be used during pregnancy only if potential benefit justifies potential risk.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Gatifloxacin and dexamethasone may be excreted in human milk. Caution should be exercised.
Pediatric use
Safety and effectiveness in pediatric patients have not been established.
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
No special precautions are necessary for patients with kidney or liver problems.
Overdose effects
Overdose through local or accidental oral administration is not likely.
Storage conditions
Store in a cool and dry place away from light. Do not use after 1 month of first opening.
Chemical structure
Dexamethasone + Gatifloxacin