Generic
Dexamethasone + Neomycin + Polymyxin B (Eye Prep)
4 brands available in the market
At a glance
Dexamethasone + Neomycin + Polymyxin B is an eye preparation used for the treatment of ocular inflammation with suspected or confirmed bacterial infection.
Description
Dexamethasone is a corticosteroid with mainly glucocorticoid activity used for its anti-inflammatory action. Neomycin is a broad-spectrum aminoglycoside antibiotic used topically for skin, ear, and eye infections. Polymyxin B is active only against gram-negative bacteria especially Pseudomonas aeruginosa.
Indications
- Bacterial eye infections
- Ocular inflammation with suspected or confirmed bacterial infection
Therapeutic class
Ophthalmic steroid - antibiotic combined preparations
Pharmacological class
Corticosteroid + Aminoglycoside + Polymyxin
Pharmacology
Dexamethasone is a corticosteroid with mainly glucocorticoid activity used for its anti-inflammatory action. Neomycin is a broad-spectrum aminoglycoside antibiotic. Polymyxin B is active only against gram-negative bacteria especially Pseudomonas aeruginosa.
Mechanism of action
Dexamethasone reduces inflammation; Neomycin inhibits bacterial protein synthesis; Polymyxin B increases bacterial cell membrane permeability to kill bacteria.
Dosage
Adult: Instill 1-2 drops into the conjunctival sac(s) of the affected eye(s) up to 4-6 times daily (may be used up to hourly in severe disease). Reduce frequency once condition improves.
Administration
For ophthalmic use only. Hold the dropper close to the eye without touching it. Place the medicine inside the lower eyelid.
Missed dose
If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.
Side effects
Common: Blurred vision, cataract, raised intraocular pressure, stinging, conjunctival hemorrhage, glaucoma, vitreous detachment, hives, rash, itching, eye pain.
Precautions & warnings
Prolonged use may cause glaucoma, optic nerve damage, posterior subcapsular cataract formation, and increased risk of secondary ocular infections. Increased risk of perforations in diseases causing thinning of the cornea or sclera. Corticosteroids may mask or worsen infections. Regular IOP monitoring recommended if used for ≥10 days.
Contraindications
Hypersensitivity; epithelial herpes simplex keratitis, vaccinia, varicella, and other viral diseases of cornea and conjunctiva; after uncomplicated removal of a corneal foreign body.
Drug interactions
No adequate information on drug interactions is available.
Food interactions
Can be used with or without food.
Use in pregnancy
Pregnancy Category C. Corticosteroids may be teratogenic. Should be used during pregnancy only if potential benefit justifies potential risk. Prolonged or repeated use may increase risk of intra-uterine growth retardation.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Systemically administered corticosteroids appear in human milk and could suppress growth. Unknown whether topical administration could result in sufficient systemic absorption.
Pediatric use
Safety and effectiveness in pediatric patients have not been established.
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
No special precautions are necessary for patients with kidney or liver problems.
Overdose effects
No adequate information on overdose is available.
Storage conditions
Store in a cool and dry place.
Chemical structure
Dexamethasone + Neomycin + Polymyxin B (Eye Prep)