Dextromethorphan Hydrobromide

Dextromethorphan Hydrobromide is a cough suppressant which has a central action on the cough centre in the medulla. Although structurally related to morphine, it has no analgesic properties and in general it has little sedative activity. Addiction has not been observed after the administration of rather large doses for prolonged period.

• Chronic dry cough
• Unproductive cough
• Acute dry cough interfering with normal function or sleep

Dextromethorphan Hydrobromide is a cough suppressant which has a central action on the cough centre in the medulla. Although structurally related to morphine, it has no analgesic properties and in general it has little sedative activity.

Dextromethorphan acts on the cough centre in the medulla, raising the threshold for the cough reflex to suppress cough.

Adults & Children (>12 years): 10-20 mg (1-2 tsp) every 4 hours OR 30 mg (3 tsp) every 6-8 hours; max 120 mg (12 tsp) in 24 hours.
Children (6-12 years): 5-10 mg (½-1 tsp) every 4 hours OR 15 mg (1½ tsp) every 6-8 hours; max 60 mg (6 tsp) in 24 hours.
Children (2-6 years): 2.5-5 mg (¼-½ tsp) every 4 hours OR 7.5 mg (¾ tsp) every 6-8 hours; max 30 mg (3 tsp) in 24 hours.
Children under 2 years: Use only as directed by the physician.

Measure with a measuring cup, shake well before use. Take with or without food, but it is better to take it at a fixed time.

If you miss a dose of Dextromethorphan Hydrobromide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common: Sleepiness, dizziness, excitement, confusion, nausea, vomiting, diarrhea, rash.
Serious: Convulsion, respiratory depression (with overdose).

May affect driving ability (sleepiness, dizziness). Do not use for chronic cough or cough with excessive secretions. Consult doctor if cough lasts >7 days, recurs, or is accompanied by fever, rash, or headache. Avoid in liver disease.

Hypersensitivity; concomitant use with MAOIs; caution in liver disease.

TCAs, antipsychotics, anxiolytics and hypnotics, cimetidine, ciprofloxacin, domperidone, metoclopramide, mexiletine, CYP2D6 inhibitors, ritonavir, alcohol: Caution required.
Potentially Fatal: Memantine, moclobemide.

Caution is advised when consuming alcohol with Dextromethorphan Hydrobromide. Please consult your doctor.

Pregnancy Category C. Dextromethorphan may be unsafe during pregnancy. Avoid during first 3 months.

It is not known whether dextromethorphan is excreted in breast milk. Caution is advised.

Children under 2 years: use only as directed by the physician.

No specific dosage adjustment is necessary for elderly patients.

Renal impairment: Probably safe; dose adjustment may not be needed.
Hepatic impairment: Probably unsafe; avoid use.

Overdose may cause excitement, confusion, and respiratory depression. Seek medical attention.

Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.

Dextromethorphan Hydrobromide