Generic
Diacerein + Glucosamine Sulphate
23 brands available in the market
At a glance
Diacerein + Glucosamine Sulphate is a combination medicine used for the treatment of osteoarthritis, rheumatoid arthritis, and bone and joint injuries.
Description
Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage. Diacerein is an anthraquinone derivative that acts via inhibition of interleukin-1 in osteoarthritis.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Bone and Joint injuries
- Chronic low back pain
Therapeutic class
Stimulation of Cartilage formation
Pharmacological class
Cartilage Formation Stimulant
Pharmacology
Glucosamine stimulates the production of proteoglycans and increases sulfate uptake by articular cartilage. Diacerein is an anthraquinone derivative that acts via inhibition of interleukin-1 in osteoarthritis.
Mechanism of action
Glucosamine supports cartilage formation; Diacerein inhibits interleukin-1 to reduce inflammation and cartilage destruction.
Dosage
Adults and Children (>12 years): 1 tablet twice daily with food.
Renal impairment (CrCl <30): 25 mg daily.
Administration
Take with food or immediately after meals.
Missed dose
If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose.
Side effects
Common: Diarrhea, constipation, epigastric pain, heartburn, nausea, vomiting, headache, skin rashes, drowsiness, intense yellow coloring of urine.
Precautions & warnings
Caution in patients allergic to glucosamine, diacerein or shellfish; those with diabetes, asthma, alcohol dependence or liver disease. Regular monitoring of blood count, liver function and urinalysis is recommended.
Contraindications
Hypersensitivity; pregnancy and lactation.
Drug interactions
Aluminium/magnesium hydroxide antacids: Decreased absorption of diacerein.
Laxatives, antibiotics: Increased risk of diarrhea.
Fibers and phytates: Avoid co-administration.
Antidiabetic agents, doxorubicin, etoposide: May reduce effect.
Warfarin: May enhance anticoagulant activity.
Food interactions
Take with food.
Use in pregnancy
Contraindicated during pregnancy and breastfeeding.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Use in lactation
Contraindicated during pregnancy and breastfeeding.
Pediatric use
Safety and effectiveness in children under 12 years have not been established.
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
Renal impairment (CrCl <30): reduce dose to 25 mg daily.
Overdose effects
No data available regarding overdose.
Storage conditions
Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
Chemical structure
Diacerein + Glucosamine Sulphate