Generic
Diclofenac + Lidocaine Hydrochloride
28 brands available in the market
At a glance
Diclofenac + Lidocaine Hydrochloride is a combination injection used for the treatment of pain and inflammation in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout.
Description
Diclofenac is an NSAID that inhibits cyclooxygenase, reducing prostaglandin synthesis. Lidocaine is an amide-type local anesthetic that stabilizes the neuronal membrane and inhibits Na+ ion movement.
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute gout
- Musculoskeletal and joint pain
- Tendinitis, bursitis
- Postoperative pain
- Renal colic
Therapeutic class
Drugs for Osteoarthritis, Drugs used for Rheumatoid Arthritis, Non-steroidal Anti-inflammatory Drugs (NSAIDs)
Pharmacological class
NSAID + Local Anesthetic
Pharmacology
Diclofenac is an NSAID that inhibits cyclooxygenase, reducing prostaglandin synthesis. Lidocaine is an amide-type local anesthetic that stabilizes the neuronal membrane and inhibits Na+ ion movement.
Mechanism of action
Diclofenac reduces pain and inflammation by inhibiting prostaglandin synthesis; Lidocaine provides local pain relief by blocking nerve conduction.
Dosage
Adult (IM): 75 mg once daily (may increase to 75 mg bid in severe conditions); max period: 2 days.
Adult (IV - Postoperative pain): 75 mg infusion over 30-120 min or bolus, may repeat after 4-6 hours; max 2 days.
Adult (Renal colic): 75 mg (may repeat once after 30 min); max 150 mg/day.
Children (Juvenile chronic arthritis): 1-3 mg/kg/day.
Elderly: Lowest effective dose.
Administration
Administered as intramuscular injection (gluteal muscle) or intravenous infusion by healthcare professionals.
Missed dose
This medicine is given by healthcare professionals. You cannot miss a dose yourself.
Side effects
Common: GI discomfort, nausea, diarrhea, headache, injection site reactions.
Rare: Peptic ulcer, haematemesis, melena, blood dyscrasia, anaphylactoid reactions.
Lidocaine-related (CNS): Drowsiness, dizziness, confusion, lightheadedness.
Precautions & warnings
Caution in GI ulceration, haematemesis, melena, ulcerative colitis, asthma, Crohn's disease, bleeding diathesis, severe hepatic/cardiac/renal insufficiency, hypertension.
Contraindications
Active or suspected peptic ulcer or GI bleeding; aspirin or other NSAID-induced asthma, urticaria or acute rhinitis; hypersensitivity to amide-type local anesthetics; Adams-Stokes syndrome; SA, AV or intraventricular heart block.
Drug interactions
Lithium, Digoxin: Increased plasma concentrations.
Anticoagulants (warfarin): Increased risk of hemorrhage.
Cyclosporin: Increased risk of nephrotoxicity.
Methotrexate: Risk of serious toxicity.
Quinolone antibiotics: Convulsions may occur.
Other NSAIDs and steroids: Increased frequency of unwanted effects.
Diuretics: Activity may be inhibited.
Food interactions
Can be used with or without food.
Use in pregnancy
Pregnancy Category C; avoid in late pregnancy (may cause premature closure of ductus arteriosus); Category D if >30 weeks of gestation.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Diclofenac is excreted in breast milk in small quantities; use is not recommended.
Pediatric use
Juvenile chronic arthritis: 1-3 mg/kg/day may be used.
Geriatric use
Elderly or debilitated patients: lowest effective dose.
Renal / hepatic impairment
Caution in renal impairment; dose adjustment may be needed.
Overdose effects
Treatment of overdose is symptomatic.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.
Chemical structure
Diclofenac + Lidocaine Hydrochloride