Apain Plus
75mg+20mg/2mlRx৳ 15/unit
Pack: ৳ 15
৳ 15/unit
Pack: ৳ 15
At a glance
Diclofenac + Lidocaine Hydrochloride is a combination injection used for the treatment of pain and inflammation in rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and acute gout.
Indications
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute gout
- Musculoskeletal and joint pain
- Tendinitis, bursitis
- Postoperative pain
- Renal colic
Pharmacology
Diclofenac is an NSAID that inhibits cyclooxygenase, reducing prostaglandin synthesis. Lidocaine is an amide-type local anesthetic that stabilizes the neuronal membrane and inhibits Na+ ion movement.
Dosage
Adult (IM): 75 mg once daily (may increase to 75 mg bid in severe conditions); max period: 2 days.
Adult (IV - Postoperative pain): 75 mg infusion over 30-120 min or bolus, may repeat after 4-6 hours; max 2 days.
Adult (Renal colic): 75 mg (may repeat once after 30 min); max 150 mg/day.
Children (Juvenile chronic arthritis): 1-3 mg/kg/day.
Elderly: Lowest effective dose.
Side effects
Common: GI discomfort, nausea, diarrhea, headache, injection site reactions.
Rare: Peptic ulcer, haematemesis, melena, blood dyscrasia, anaphylactoid reactions.
Lidocaine-related (CNS): Drowsiness, dizziness, confusion, lightheadedness.
Use in pregnancy
Pregnancy Category C; avoid in late pregnancy (may cause premature closure of ductus arteriosus); Category D if >30 weeks of gestation.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Caution in GI ulceration, haematemesis, melena, ulcerative colitis, asthma, Crohn's disease, bleeding diathesis, severe hepatic/cardiac/renal insufficiency, hypertension.
Overdose effects
Treatment of overdose is symptomatic.
Storage conditions
Keep below 30°C temperature, away from light & moisture. Keep out of reach of children.