Diclofenac Sodium

Diclofenac Sodium is a potent NSAID with anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. It inhibits cyclooxygenase, reducing prostaglandin synthesis, which plays a major role in inflammation, pain and fever.

• Rheumatoid arthritis
• Osteoarthritis
• Ankylosing spondylitis
• Acute gout
• Dysmenorrhea
• Post-traumatic and post-operative pain
• Renal and biliary colic

Diclofenac Sodium is a potent NSAID with anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties. It inhibits cyclooxygenase, reducing prostaglandin synthesis.

Diclofenac Sodium inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis, which decreases pain, inflammation, and fever.

Adult (Oral - FC Tablet): 75-150 mg daily in 2-3 divided doses.
Adult (SR Tablet): 1 tablet daily (may increase to 150 mg/day if needed).
Adult (Dispersible Tablet): 2-3 tablets/day (max 150 mg/day).
Adult (Injection): 1 ampoule daily (2 ampoules/day in severe cases).
Adult (Suppository): 50 mg 2-3 times daily (max 150 mg/day).
Children: 1-3 mg/kg/day in divided doses.
Elderly: Lowest effective dose.

Take with food or immediately after meals. Swallow the tablet whole, do not chew, crush or break. Injection and suppository are administered by healthcare professionals.

If you miss a dose of Diclofenac Sodium, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose. Do not double the dose.

Common: GI discomfort, epigastric pain, eructation, nausea, diarrhea, headache, dizziness.
Occasional: Skin rash, peripheral edema, serum transaminase abnormalities.
Rare: Peptic ulcer, haematemesis, melena, blood dyscrasia, anaphylactoid reactions.

History of GI ulceration, haematemesis, melena, ulcerative colitis, asthma, Crohn's disease, bleeding diathesis, severe hepatic/cardiac/renal insufficiency, hypertension. Monitor LFTs. May trigger attacks in hepatic porphyria.

Hypersensitivity; active or suspected peptic ulcer or GI bleeding; aspirin or other NSAID-induced asthma, urticaria or acute rhinitis.

Lithium, Digoxin: Increased plasma concentrations.
Anticoagulants (warfarin): Increased risk of hemorrhage.
Antidiabetic agents: No effect on clinical effect.
Cyclosporin: Increased risk of nephrotoxicity.
Methotrexate: Risk of serious toxicity (within 24 hours).
Quinolone antibiotics: Convulsions may occur.
Other NSAIDs and steroids: Increased frequency of unwanted effects.

Take with food.

Pregnancy Category C. Avoid use of NSAIDs starting at 30 weeks of gestation; use in first trimester is inconclusive.

Diclofenac is excreted in breast milk in small quantities; no undesirable effects on the infant are expected.

Children: 1-3 mg/kg/day (not recommended for other indications except juvenile rheumatoid arthritis).

Elderly and debilitated patients should use the lowest effective dose.

Caution in renal impairment; dose adjustment may be needed.

Treatment of overdose is symptomatic.

Store in a cool and dry place, protected from light below 30°C. Keep out of reach of children.

Diclofenac Sodium