Generic
Dioxybenzone + Hydroquinone + Octyldimet + Oxybenzone
1 brands available in the market
At a glance
Dioxybenzone + Hydroquinone + Octyldimet + Oxybenzone is a combination cream used for the treatment of chloasma, melasma, freckles, senile lentigines, and hyperpigmentation.
Description
Hydroquinone is a topical depigmenting agent that suppresses melanocyte metabolic processes and prevents melanin production. Octyldimethyl P-aminobenzoate, Dioxybenzone, and Oxybenzone are sunscreens that absorb UV rays and protect the skin from sun damage.
Indications
- Chloasma
- Melasma
- Freckles
- Senile lentigines
- Hyperpigmentation
Therapeutic class
Sunblock Preparation
Pharmacological class
Topical Depigmenting + Sunscreen
Pharmacology
Hydroquinone suppresses melanocyte metabolic processes and prevents melanin production. Octyldimethyl P-aminobenzoate, Dioxybenzone, and Oxybenzone absorb UV rays to protect the skin from sun damage.
Mechanism of action
Hydroquinone lightens the skin by suppressing melanin production; sunscreen components prevent repigmentation by protecting against UV rays.
Dosage
Adult: Apply a thin layer to the affected area twice daily and rub in well.
Administration
For external use only. Test for skin sensitivity on a small patch of skin for 24 hours. Avoid contact with eyes and lips. Do not apply to cut or abraded skin.
Missed dose
If you miss a dose, apply it as soon as possible. However, if it is almost time for your next application, skip the missed dose.
Side effects
Common: Transient erythema, mild burning sensations, hyperpigmentation, staining, corneal opacities.
Serious (with systemic absorption): Tremors, convulsions.
Occasional: Hypersensitivity (localized contact dermatitis).
Precautions & warnings
If no bleaching effect is noted after 2 months of treatment, discontinue. Discontinue if itching, vesicle formation, or excessive inflammation occurs. Limit application to face, neck, hands, and arms. Avoid excessive sun exposure.
Contraindications
Hypersensitivity; sunburn or depilatory usage; children under 12 years.
Drug interactions
Peroxide: Concurrent use may result in transient dark staining of skin areas due to oxidation of hydroquinone.
Food interactions
Can be used with or without food.
Use in pregnancy
Should be used during pregnancy only when clearly indicated.
Pregnancy Category: N/A — always consult a doctor before taking during pregnancy.
Use in lactation
It is not known whether hydroquinone is excreted in human milk; caution is advised.
Pediatric use
Safety and efficacy in children under 12 years have not been established.
Geriatric use
No specific dosage adjustment is necessary for elderly patients.
Renal / hepatic impairment
No special precautions are necessary for patients with kidney or liver problems.
Overdose effects
No systemic adverse reactions have been reported; excessive use may cause skin irritation.
Storage conditions
Keep below 30°C temperature, away from light & moisture.
Chemical structure
Dioxybenzone + Hydroquinone + Octyldimet + Oxybenzone