Generic
Dopamine Hydrochloride
7 brands available in the market
At a glance
Dopamine Hydrochloride is used for the treatment of low blood pressure due to heart attack, infection, heart surgery, or trauma. It increases blood pressure by increasing pumping capacity of the heart and improving blood flow, and may help prevent kidney failure in critically ill patients.
Description
Dopamine Hydrochloride is a sympathomimetic agonist used for low blood pressure and heart failure. It works on dopamine and adrenergic receptors to improve blood flow and cardiac output.
Indications
- Heart failure
- Low blood pressure
Therapeutic class
Inotropic-sympathomimetics
Pharmacological class
Dopamine
Pharmacology
Dopamine stimulates α, β and dopamine receptors. At lower doses it produces renal and mesenteric vasodilation, while at higher doses it stimulates cardiac stimulation and renal vasodilation.
Mechanism of action
Dopamine stimulates dopaminergic receptors at lower doses producing renal and mesenteric vasodilation, while at higher doses stimulates both dopaminergic and α-adrenergic receptors producing cardiac stimulation and renal vasodilation.
Dosage
Adult Dose: Hemodynamic conditions: 1-5 mcg/kg/min IV (low dose), 5-15 mcg/kg/min (medium dose), 20-50 mcg/kg/min (high dose). Increase by 1-4 mcg/kg/min at 10-30 min intervals. Titrate to desired response.
Child Dose: 1-5 mcg/kg/min IV, increased to 5-20 mcg/kg/min; not to exceed 50 mcg/kg/min.
Administration
Your doctor or nurse will give you this medicine. Kindly do not self administer.
Missed dose
If you miss a dose of Dopamine Hydrochloride, please consult your doctor.
Side effects
Common Side Effects:
- Flushing (sense of warmth in the face, ears, neck and trunk)
- Headache
- Increased heart rate
- Palpitations
Precautions & warnings
- Intended for use in hospitalized patients.
- Regular monitoring of heartbeat, blood pressure, urine output, liver and kidney function required.
- Inform your doctor if you are pregnant, planning pregnancy or breastfeeding.
Contraindications
- Pheochromocytoma
- Uncorrected tachyarrhythmias
- Ventricular fibrillation
- Hypersensitivity
Drug interactions
Cyclopropane and halogenated hydrocarbon anaesthetics may precipitate ventricular arrhythmias. MAO inhibitors prolong and increase dopamine effects. Ergots potentiate vasoconstriction.
Food interactions
It is not known whether it is safe to consume alcohol with Dopamine Hydrochloride. Please consult your doctor.
Use in pregnancy
Dopamine Hydrochloride may be unsafe during pregnancy. Animal studies have shown harmful effects. Doctor will weigh benefits and risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Dopamine Hydrochloride is probably safe during breastfeeding. Limited human data suggests no significant risk to the baby.
Pediatric use
Safety and efficacy in children not established.
Geriatric use
Limited information available regarding dose adjustment for elderly patients.
Renal / hepatic impairment
Renal impairment: Limited information available on use in kidney disease. Consult your doctor.
Hepatic impairment: Limited information available on use in liver disease. Consult your doctor.
Overdose effects
In case of accidental overdosage, reduce rate or temporarily discontinue. Use phentolamine if needed.
Storage conditions
Store below 25°C, away from light & moisture. Keep out of reach of children.
Chemical structure
Dopamine Hydrochloride