Generic
Erythromycin (Vet)
1 brands available in the market
At a glance
Erythromycin Thiocyanate, Sulphadiazine and Trimethoprim combination is a water-soluble veterinary antibiotic powder used to treat bacterial infections in poultry, calves, foals, and fish. It is effective against both gram-positive and gram-negative bacteria. It is especially effective when other antibiotics fail due to resistance. It is administered through drinking water or direct oral administration.
Description
This preparation is a water-soluble antibiotic powder containing a combination of three potent antibacterial agents. Erythromycin is a macrolide antibiotic highly effective against gram-positive bacteria and Mycoplasma. Sulphadiazine and Trimethoprim together create a synergistic effect active against a wide range of bacteria. This combination is specially indicated when other antibiotics and chemotherapeutics fail due to resistance problems
Indications
পোলট্রি (Poultry): এই প্রস্তুতি গ্রাম-পজিটিভ ও গ্রাম-নেগেটিভ ব্যাকটেরিয়া দ্বারা সৃষ্ট বিভিন্ন রোগের চিকিৎসায় নির্দেশিত, যেমন: পুলোরাম রোগ (Pullorum disease) ফাউল টাইফয়েড (Fowl typhoid) ফাউল কলেরা (Fowl cholera) কোলিব্যাসিলোসিস (Colibacillosis) সেপ্টিসেমিয়া (Septicemia) নেক্রোটিক এন্টারাইটিস (Necrotic enteritis) অনির্দিষ্ট এন্টারাইটিস (Nonspecific enteritis) শ্বাসতন্ত্রের রোগ (CRD, ব্রঙ্কোপনিউমোনিয়া) মূত্র ও জননতন্ত্রের রোগ কক্সিডিওসিস (Coccidiosis) বাছুর ও ঘোড়ার বাচ্ছা (Calves & Foals): শ্বাসতন্ত্র ও গ্যাস্ট্রোইনটেস্টাইনাল ট্র্যাক্টের সংক্রমণ যেমন: ব্রঙ্কোপনিউমোনিয়া (Bronchopneumonia) ব্রঙ্কাইটিস (Bronchitis) ডায়রিয়া (Diarrhea) এন্টারাইটিস (Enteritis) স্কোর (Scour) মাছ (Fish): গ্রাম-পজিটিভ কক্কি সংক্রমণ (Gram-positive cocci infections)
Therapeutic class
Anti-Bacterial (Veterinary) – Macrolide Antibiotic + Sulphonamide + Antifolate
Pharmacology
Erythromycin is a macrolide antibiotic that binds to the 50S ribosomal subunit, inhibiting bacterial protein synthesis. It is highly effective against gram-positive bacteria and Mycoplasma, and also effective against some gram-negative bacteria such as Neissaria spp. and Haemophilus spp. Sulphadiazine inhibits the biosynthesis of PABA to dihydrosulphonic acid, and Trimethoprim inhibits the biosynthesis of tetrahydrofolic acid from dihydrofolic acid. The combined action creates a synergistic effect against a wide range of bacteria
Dosage
Poultry: 0.5 to 1.0 gm per liter of drinking water for 3-5 days. The medicated water should be freshly prepared each day and birds should not have access to any other drinking water during treatment . Calves/Foals: 7.5 g per 50 kg body weight for 3-5 days. Or as directed by the registered veterinary physician . Fish: 1 g per 10 kg body weight for 3-5 days. Or as directed by the fisheries expert .
Side effects
Common side effects: No side effects observed at recommended doses . Rare side effects: No side effects observed at recommended doses. Long-term use may cause hematological reactions and crystalluria .
Precautions & warnings
Oral erythromycin should not be used in ruminants as diarrhea may occur . Medicated water should be freshly prepared each day . Treatment should be stopped before the specified withdrawal period before slaughter. Withdrawal Period: Eggs: 6 days Meat: 5 days
Contraindications
This preparation is contraindicated in animals with hypersensitivity to Erythromycin, Sulphadiazine, or Trimethoprim
Drug interactions
Other macrolide antibiotics Chloramphenicol Tylosin Lincosamide With food: There are no specific foods that should be excluded from diet when receiving this medication .
Overdose effects
This drug is relatively non-toxic . Overdosage may lead to diarrhea, abdominal pain, and neurotoxicity
Storage conditions
Protect from light, store in a cool and dry place. Keep out of reach of children